NEW ANTIMICROBIAL AGENTS Russian patent published in 2014 - IPC C07D413/14 A61K31/422 A61K31/496 A61K31/445 A61P31/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: given invention refers to a compound of formula its stereoisomers, including R and S isomers, wherein: 'A' represents N; Y and Y' represent O; '---' is absent; R¹ and R² are identical or different, and independently represent hydrogen or C_1-12 alkyl; R³ represents hydrogen; R⁴ represents heteroaryl which can be optionally substituted in any acceptable position by one or more substitutes R^a; Z represents -(CH₂)_n-heteroaryl which can be optionally substituted in any acceptable position by one or more substitutes R^a; T, U, V and W are identical or different, and independently represent hydrogen or halogen; R^a is independently specified in hydrogen, halogen, C_1-12 alkyl, C_1-12 haloalkyl, -C(=Y)OR⁷, -(CH₂)_nYR⁷, each of which can be optionally substituted in any acceptable position by halogen; R⁷ represents hydrogen or C_1-12 alkyl; m represents 1; m′ represents 0; n represents 1; wherein: the above heteroaryl is specified in 1,2,3-triazolyl, pyridinyl, 1-oxypyridinyl (pyridinyl-N-oxide), pyrazinyl, isoxazolyl, imidazo[1,2-α]pyrimidinyl, imidazo[1,2-α]pyrazinyl. The compounds of the given invention are applicable to prevent, relieve and/or treat bacterial infections in an individual. The bacterial infection is caused by the drug-resistant species Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella, acid-resistant species like Mycobacterium tuberculosis, as well as linezolid-resistant species Staphylococcus and Enterococcus.

EFFECT: phenyloxazolidinone compounds as antimicrobial agents.

12 cl, 8 tbl, 3 ex