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2 522 961

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(51)

IPC

G01N33/52(2006-01-01)

(21) (22)

Application

2012153354/15, 2012-12-10

(24)

Start date

2012-12-10

(22)

Actual filing date

2012-12-10

(45)

Published

2014-07-20

(72)

Inventor

Kozhevnikov Vladimir SergeevichZinnatova Elena VladimirovnaBorisov Vjacheslav Igorevich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Institut Klinicheskoj Immunologii" Sibirskogo Otdelenija Rossijskoj Akademii Meditsinskikh Nauk Soramn)

METHOD FOR DETERMINING MARKER OF DEVELOPING RHEUMATOID ARTHRITIS BY DETECTING SHORTENING OF RELATIVE LENGTH OF TELOMERS ON SINGLE CHROMOSOMES IN PERIPHERAL BLOOD T-LYMPHOCYTES Russian patent published in 2014 - IPC G01N33/52

Abstract RU 2522961 C1

FIELD: medicine.

SUBSTANCE: method consists in detecting shortening of a relative length of telomeres on single chromosomes of peripheral blood T-lymphocytes by means of quantitative fluorescence in situ hybridisation (Q-FISH). The result telomere length is calculated as a mean fluorescence intensity of the telomeres of the single chromosome (for each arm separately) related to a mean fluorescence of the telomeres of all chromosomes in a metaphase. Shortening of the relative length of the telomeres on a short arm of the 4^th chromosome in patients with rheumatoid arthritis as compared to donors is considered as a marker of developing the disease.

EFFECT: invention enables adequate information value and specificity of determining a risk of developing of the autoimmune pathology of the given type.

3 dwg, 1 tbl, 2 ex

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RU 2 522 961 C1

Authors

Kozhevnikov Vladimir Sergeevich

Zinnatova Elena Vladimirovna

Borisov Vjacheslav Igorevich

Dates

2014-07-20—Published

2012-12-10—Filed