METHOD FOR DETERMINING MARKER OF DEVELOPING RHEUMATOID ARTHRITIS BY DETECTING SHORTENING OF RELATIVE LENGTH OF TELOMERS ON SINGLE CHROMOSOMES IN PERIPHERAL BLOOD T-LYMPHOCYTES Russian patent published in 2014 - IPC G01N33/52 

Abstract RU 2522961 C1

FIELD: medicine.

SUBSTANCE: method consists in detecting shortening of a relative length of telomeres on single chromosomes of peripheral blood T-lymphocytes by means of quantitative fluorescence in situ hybridisation (Q-FISH). The result telomere length is calculated as a mean fluorescence intensity of the telomeres of the single chromosome (for each arm separately) related to a mean fluorescence of the telomeres of all chromosomes in a metaphase. Shortening of the relative length of the telomeres on a short arm of the 4th chromosome in patients with rheumatoid arthritis as compared to donors is considered as a marker of developing the disease.

EFFECT: invention enables adequate information value and specificity of determining a risk of developing of the autoimmune pathology of the given type.

3 dwg, 1 tbl, 2 ex

Similar patents RU2522961C1

Title Year Author Number
METHOD FOR IDENTIFICATION OF GENETIC MARKERS OF TELOMERE LENGTH REGULATION 2018
  • Abdulkina Liliya Rinatovna
  • Shakirov Evgenij Vitalevich
  • Valeeva Liya Rashitovna
RU2684702C1
METHOD OF MEASURING LENGTH OF TELOMERES OF UMBILICAL BLOOD LEUKOCONCENTRATE CELLS 2010
  • Smoljaninov Aleksandr Borisovich
  • Khurtsilava Otari Givievich
  • Smirnova Natal'Ja Vladimirovna
  • Novikova Polina Jur'Evna
RU2434940C1
METHOD OF MARKING HUMAN 7TH CHROMOSOME IN METAPHASIC AND INTERPHASIC CELLS 2009
  • Jurov Jurij Borisovich
  • Aleksandrov Ivan Aleksandrovich
  • Solov'Ev Il'Ja Vladimirovich
  • Jurov Ivan Jur'Evich
  • Vorsanova Svetlana Grigor'Evna
RU2425890C2
RECOMBINANT PLASMID DNA pYAII-39, USED FOR 4TH AND 9TH HUMAN CHROMOSOME MARKING IN METAPHASIC AND INTERPHASIC CELLS 2006
  • Jurov Jurij Borisovich
  • Aleksandrov Ivan Aleksandrovich
  • Vorsanova Svetlana Grigor'Evna
  • Solov'Ev Il'Ja Vladimirovich
RU2325441C1
RECOMBINANT PLASMID DNA ALPHA-R-12 DESIGNATED FOR MARKING 6-TH HUMAN CHROMOSOME IN METAPHASE IN INTERPHASE CELLS 2004
  • Jurov Ju.B.
  • Jakovlev A.G.
  • Vorsanova S.G.
  • Solov'Ev I.V.
RU2265060C1
METHOD OF LABELLING MANЪS 11TH CHROMOSOME,RECOMBINATION PLASMIDE OF GENOME DEOXYRIBONUCLEIC ACID PHS 53 FOR LABELLING AND METHOD OF PRODUCING FRAGMENT OF DEOXYRIBONUCLEIC ACID PHS 53 0
  • Gindilis Viktor Mironovich
  • Zajtsev Igor Zakvanovich
  • Yakovlev Aleksandr Georgievich
  • Yurov Yurij Borisovich
  • Shapiro Yurij Abramovich
SU1203108A1
RECOMBINANT PLASMID DNA PYAI 960 DESIGNATED FOR HUMAN 18-TH CHROMOSOME MARKING 2000
  • Jurov Ju.B.
  • Vorsanova S.G.
  • Aleksandrov I.A.
RU2161199C1
METHOD AND DEVICE FOR DETERMINING CHROMOSOME STRUCTURE 2005
  • Vallabkhaneni Ramesh
RU2471871C2
RECOMBINANT PLASMID DNA ALPHA R 1-6 DESIGNATED FOR MARKING THE 13-TH AND 21-D HUMAN CHROMOSOMES 1995
  • Solov'Ev I.V.
  • Jurov Ju.B.
  • Vorsanova S.G.
  • Jakovlev A.G.
  • Demidova I.A.
RU2087534C1
METHOD OF SINGLE-STEP TELOMERE LENGTH AND POPULATION DIVISION QUANTITY MEASUREMENT OF PROLIFERATIVE CELLS IN VITRO 2010
  • Kozhevnikov Vladimir Sergeevich
  • Borisov Vjacheslav Igorevich
RU2443777C2

RU 2 522 961 C1

Authors

Kozhevnikov Vladimir Sergeevich

Zinnatova Elena Vladimirovna

Borisov Vjacheslav Igorevich

Dates

2014-07-20Published

2012-12-10Filed