METHOD OF EMERGENCY PREVENTION AND TREATMENT OF BRUCELLOSIS Russian patent published in 2014 - IPC A61K39/10 A61P31/00 

FIELD: veterinary medicine.

SUBSTANCE: method of emergency prevention and treatment of brucellosis, comprising simultaneous intramuscular administration of antibiotic resistance version of the vaccine strain of Brucella and antibrucellar preparation, characterised in that as the particular preparation the cyprolet- resistant version of strain of Brucella B.abortus 82 CR is used at a dose of 1.10⁹ m.c. , and as the antibacterial preparation the ciprofloxacin (cyprolet) is used which is administered at a dose of 1 and 3 mL/kg, 2 times per day for 5-7 days. The cyprolet- resistant version of Brucella B.abortus 82 CR is obtained by growing a stock culture of Brucella B.abortus 82 on MPGGA, containing 5, 10, 20 mg per 1 ml of medium. Prevention and treatment of brucellosis is carried out 1-10 days prior to the period of greatest risk of infection and in the period of greatest risk of infection.

EFFECT: method increases effectiveness of treatment and prevention of brucellosis due to interference of avirulent strain of Brucella in relation to brucellosis pathogen, induction by cyprolet- resistant version of vaccine strain of mediators of immunogenesis - activators of phagocytosis-cytokines, powerful antibacterial agent cyprolet, which together provide the suppression of reproduction of microbial DNA and death of parasite.

3 cl, 8 ex