MAGNETICALLY CONTROLLED SORBENT AGENT FOR BILIRUBIN ELIMINATION FROM BIOLOGICAL FLUIDS Russian patent published in 2014 - IPC G01N33/543 A61K47/00 B01J20/06 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and is applicable for treating endogenous intoxication caused by high plasma bilirubin concentrations accompanying various pathologies. Substance of a method: a surface of a magnetically controlled sorbent agent is coated with hydrophobic ligands either in the form of 3-mercaptopropionic acid methyl ester, or in the form of polymeric octadecylhydrosilicic acid, or in the form of polymeric hydrosilicic acid, containing covalently attached octadecyl ligands. Magnetite micro- and nanoparticles are presented by Fe₃O₄. The total bilirubin recovery rate in the sorbent agent is determined by a lyophilised bovine serum dry powder. The bilirubin content is determined by formula: AB(%)=100-(A460 nm test/A460 nm reference)×100, wherein AB(%) is a percentage of the absorbed bilirubin; A460 nm test is an optical density of the solution contacted the sorbent agent; A460 nm reference is an optical density of the solution before contact with the sorbent agent; 460 nm is a wave length whereat bilirubin has the maximum optical absorption.

EFFECT: declared magnetically controlled sorbent agent possesses a developed specific surface, a reasonably good sorption capacity, as well as is characterised by a high degree of efficacy of bilirubin elimination from biological fluids, eg blood plasma (more than 30% lower bilirubin for one sorption cycle).

7 cl, 3 tbl, 4 ex