METHOD OF IDENTIFYING COMPOUND, SUITABLE FOR TREATING INFLAMMATORY CONDITION OF ORAL CAVITY Russian patent published in 2014 - IPC G01N33/50 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of pharmaceutics and represents a method of identifying a compound, suitable for treatment of gingivitis, which includes an interaction of the first gingival sample, obtained from a mammal, suffering from gingivitis, with an analysed compound; an interaction of the second gingival sample from the oral cavity of a mammal with a positive control - a compound, suppressing the expression of one or more matrix metalloproteinases (halogenated diphenyl ether); measurement of a degree, with which an expression of one or more matrix metalloproteinases is suppressed by means of the analysed compound; measurement of a degree, with which the expression of one or more matrix metalloproteinases is suppressed by means of the positive control; and comparison of a degree, with which the expression of one or more matrix metalloproteinases is suppressed by means of the analysed compound, with a degree, with which the expression of one or more matrix metalloproteinases is suppressed by means of the positive control; in which the analysed compound, which suppresses the expression of one or more matrix metalloproteinases in an equal or a higher degree than the positive control, is a compound, suitable for treatment of gingivitis; where one or more matrix metalloproteinases, for which the expression is measured, include, at least, MMP-9 and MMP-13.

EFFECT: elaboration of the method of identifying the compound, suitable for treatment of gingivitis.

7 cl, 2 ex, 4 tbl, 3 dwg