METHOD OF CORRECTING HAEMOSTATIC DISORDERS IN CASE OF CHRONIC CALCULOUS CHOLECYSTITIS AT BACKGROUND OF CHRONIC HEPATITIS OR CIRRHOSIS OF LIVER Russian patent published in 2014 - IPC A61K31/10 A61K31/13 A61K38/36 A61P7/00 

FIELD: medicine.

SUBSTANCE: to correct haemostatic disorders in case of chronic calculous cholecystitis at the background of chronic hepatitis or cirrhosis of liver, preoperative correction of haemostasis with the preparation prothromplex 600, introduced intravenously at a rate not higher than 2 ml/min in a dose of 20 IU/kg of the patient's body weight, is carried out 3 days before endosurgical treatment. After that, on the first day after operation 20 IU/kg of prothromplex 600 and additionally 10 mg/kg of etamsylate and 25 mg/kg of aminomethyl are introduced intravenously. The preparations are introduced 1 time per day for 3 days with obligatory control of haemostasis indices.

EFFECT: method makes it possible to enhance the clinical effect due to an improvement of haemostasis system indices, connected with an increase of quantitative indices of a coagulation link, at the background of normalisation of the aggregation activity of platelets, as well as an arrest of hypocoagulation due to normalisation of the prothrombin complex, which makes it possible to twice reduce the treatment duration.

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