METHOD OF DETERMINING INDICATIONS FOR TRANSFUSION OF PLASMA-COAGULATION HAEMOSTASIS CORRECTORS IN CARDIAC SURGERY Russian patent published in 2015 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: for patients with increased bleeding in perioperative period test of thrombin generation is carried out in plasma with patient's platelets and in platelet- depleted plasma; decision about introduction of certain haemostatic medication is taken on the basis of values peak thrombin and lag time in both samples. If values pk<200 nmole/l, and lagT>4 in both samples patient is subjected to transfusion of prothrombin complex concentrate in dose 15 IE/kg; if in plasma with patient's platelets pk<200 nmole/l and lagT>4, with simultaneous normal values pk and lagT in platelet-depleted plasma, transfusion of platelet mass in amount 1 dose/10 kg is realised, and if values pk<200 nmole/l and lagT>4 in platelet-free plasma and normal values pk and lagT in plasma with patient's platelets, transfusion of fresh-frozen plasma in volume 15 ml/kg is realised. Invention can be useful for prevention of development of fatal postoperative haemorrhages in cardiac surgery patients.

EFFECT: increase of haemostatic therapy efficiency in case of haemorrhages in cardiac surgery practice, reduction of quantity of complications after transfusion of haemostasis correctors, diagnostics and monitoring of injury to separate units of haemostasis system in cardiac surgery patients before development of laboratory signs of hypocoagulation.

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