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2 526 619

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IPC

C07D277/06(2006-01-01)

(21) (22)

Application

2012153416/04, 2012-12-12

(24)

Start date

2012-12-12

(22)

Actual filing date

2012-12-12

(45)

Published

2014-08-27

(72)

Inventor

Ershov Andrej Jur'EvichNasledov Dmitrij Grigor'EvichNasonova Ksenija ViktorovnaShamanin Valerij Vladimirovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Vysokomolekuljarnykh Soedinenij Rossijskoj Akademii Nauk

METHOD OF OBTAINING (2R,4R)-2-ALKYL-3-(2-MERCAPTOBENZOYL)-1,3-THIAZOLIDINE-4-CARBOXYLIC ACIDS Russian patent published in 2014 - IPC C07D277/06

Abstract RU 2526619 C2

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining derivatives of (2R,4R)-2-alkyl-3-(2-mercaptobenzoyl)-1,3-thiazolidine-4-carboxylic acids - potential antihypertensive substances, inhibitors of angiotensin-converting enzyme (ACE). Method of obtaining (2R,4R)-2-alkyl-3-(2-mercaptobenzoyl)-1,3-thiazolidine-4-carboxylic acids includes acylation of 2-alkyl-1,3-thiazolidine-4-carboxylic acids with dichloranhydride of dithiosalicylic acid. In the basis of target product synthesis used is natural amino acid L-cysteine and aliphatic or fatty-aromatic aldehydes, containing from 2 to 8 carbon atoms. Compounds of formula (I) , where R=C₂H₅, iso-C₄H₉, CH₂CH₂C₆H₅, substituents, given in formula stand for: C₂H₅ - ethyl, iso-C₄H₉ - isobutyl, CH₂CH₂C₆H₅ - phenylethyl, are obtained.

EFFECT: optically pure final products with application of natural or commercially available compounds.

10 ex

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RU 2 526 619 C2

Authors

Ershov Andrej Jur'Evich

Nasledov Dmitrij Grigor'Evich

Nasonova Ksenija Viktorovna

Shamanin Valerij Vladimirovich

Dates

2014-08-27—Published

2012-12-12—Filed