MILD CATIONIC MITOCHONDRIAL UNCOUPLERS Russian patent published in 2014 - IPC C07D311/88 A61K31/352 A61P9/00 

Abstract RU 2527519 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds, capable of providing uncoupling of respiration of mitochondria in direct dependence on the value of their membrane potential and causing mild uncoupling - reversible reduction of the membrane potential of the mitochondria, which does not cause substantial/physiologically meaningful suppression of respiration, an injury to the respiratory chain components or impairment of physic-chemical properties of mitochondrial membranes, and can be applied in medicine and biology. The said compound has a structure , where R1 and R3 are hydrogen atoms, R2 and R4 are hydrogen atoms independently on each other or either substituted or non-substituted C1-C4 alkyl groups; R2, bound with R5; or R4 with R6 form either substituted or non-substituted 1,3-propylene; R5, R6, R7 and R8 independently on each other represent a hydrogen atom or methyl; n=1; A is pharmacologically acceptable anion.

EFFECT: claimed are the mild uncouplers and based on them compositions for application in biology and medicine.

15 cl, 7 dwg, 6 ex

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Authors

Skulachev Vladimir Petrovich

Skulachev Maksim Vladimirovich

Zinovkin Roman Alekseevich

Severin Fedor Fedorovich

Antonenko Jurij Nikolaevich

Zorov Dmitrij Borisovich

Plotnikov Egor Jur'Evich

Isaev Nikolaj Konstantinovich

Silachev Denis Nikolaevich

Knorre Dmitrij Alekseevich

Dates

2014-09-10Published

2010-06-24Filed