FIELD: chemistry.
SUBSTANCE: invention relates to compounds, capable of providing uncoupling of respiration of mitochondria in direct dependence on the value of their membrane potential and causing mild uncoupling - reversible reduction of the membrane potential of the mitochondria, which does not cause substantial/physiologically meaningful suppression of respiration, an injury to the respiratory chain components or impairment of physic-chemical properties of mitochondrial membranes, and can be applied in medicine and biology. The said compound has a structure , where R1 and R3 are hydrogen atoms, R2 and R4 are hydrogen atoms independently on each other or either substituted or non-substituted C1-C4 alkyl groups; R2, bound with R5; or R4 with R6 form either substituted or non-substituted 1,3-propylene; R5, R6, R7 and R8 independently on each other represent a hydrogen atom or methyl; n=1; A is pharmacologically acceptable anion.
EFFECT: claimed are the mild uncouplers and based on them compositions for application in biology and medicine.
15 cl, 7 dwg, 6 ex
Authors
Dates
2014-09-10—Published
2010-06-24—Filed