METHOD FOR ON BODY BY TARGET DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES IN MITOCHONDRIA, PHARMACEUTICAL COMPOSITION FOR ITS REALIZATION AND COMPOUND USED FOR THIS AIM Russian patent published in 2008 - IPC A61K31/00 A61K31/122 A61K31/665 A61P35/00 A61P39/06 A61P43/00 C07K4/00 C07F9/54

Abstract RU 2318500 C2

FIELD: biology, medicine, organic chemistry.

SUBSTANCE: invention proposes compound of the general formula (I): wherein A means effector group; L means a linker link; B represents Skulachev-ion Sk or charged hydrophobic peptide. Compound can be used in preparing a pharmaceutical composition for target (directed) delivery of active substances in mitochondria carried out by electrochemical potential of hydrogen ions into mitochondria. Also, invention can be useful in treatment of diseases and states associated with disturbance of normal function of mitochondria, in particular, diseases associated with increased formation of free radicals and active forms of oxygen. The claimed invention owing to directed accumulation of biologically active substance in mitochondria provides enhancing the effectiveness of substance, to decrease total dose, probability and strength of adverse effects.

EFFECT: improved and valuable properties of method and pharmaceutical composition.

26 cl, 14 dwg, 16 ex

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RU 2 318 500 C2

Authors

Skulachev Vladimir Petrovich

Dates

2008-03-10—Published

2005-10-18—Filed