COMPOSITIONS AND METHODS FOR IMPROVING MITOCHONDRIAL FUNCTION AND TREATING NEURODEGENERATIVE DISEASES AND COGNITIVE DISORDERS Russian patent published in 2021 - IPC A61K31/195 A61P3/04 A61P3/06 A61P3/10 A61P9/00 A61P25/00 A61P25/28 

Abstract RU 2745439 C2

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, namely to a composition for treatment or prevention of a condition associated with mitochondrial dysfunction.The pharmaceutical composition for treatment or prevention of a condition associated with mitochondrial dysfunction that contains an effective amount of Urolithin, the specified condition having been selected from a group consisting of obesity, a reduced metabolic rate, the metabolic syndrome, diabetes mellitus, a cardiovascular disease, hyperlipidemia, a neurodegenerative disease, a cognitive function or disorder, mood disorders, stress and anxiety disorders; with Urolithin having been selected from ae group consisting of Urolithin A, Urolithin B, Urolithin C and Urolithin D.A method of treating or preventing a condition associated with mitochondrial dysfunction selected from the group consisting of obesity, decreased metabolic rate, the metabolic syndrome, diabetes mellitus, a cardiovascular disease, hyperlipidemia, a neurodegenerative disease, a cognitive function or disorder, mood disorder, stress and anxiety disorders, including: administering a therapeutically effective amount of urolithin to a subject that needs it, the urolithin having been selected from a group consisting of Urolithin A, Urolithin B, Urolithin C and Urolithin D.The use of Urolithin for the preparation of a pharmaceutical product for treatment or prevention of a condition associated with mitochondrial dysfunction selected from a group consisting of obesity, a reduced metabolic rate, the metabolic syndrome, diabetes mellitus, a cardiovascular disease, hyperlipidemia, a neurodegenerative disease, a cognitive function or disorder, mood disorders, stress and anxiety disorders; wherein the urolithin has been selected from a group consisting of Urolithin A, Urolithin B, Urolithin C and Urolithin D..

EFFECT: above compounds and compositions based on them are effective for treatment or prevention of a condition associated with mitochondrial dysfunction.

39 cl, 7 tbl, 21 ex, 49 dwg

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RU 2 745 439 C2

Authors

Rinsh Kristofer L.

Blanko-Boze Uilyam

Shnajder Bernard

Tomas Charlz

Sandi Karmen

Overks Jokhan

Andre Penelopa

Khutkuper Rikhardus

Pirinen Ejya

Mushirud Lorent

Genu David

Dates

2021-03-25Published

2011-12-23Filed