NON-INVASIVE DIAGNOSTIC TECHNIQUE FOR LACTOSE INTOLERANCE Russian patent published in 2014 - IPC G01N33/497 A61B5/83 A61B6/00 A61B5/97 

FIELD: medicine.

SUBSTANCE: oral air hydrogen of a person being tested is detected to diagnose bacterial overgrowth syndrome (BOS) by determining the pre-test initial hydrogen content; that is followed by measuring the load hydrogen content 15 and 30 min after the test load. A test solution represents lactulose in a dose of 1 g per 1 kg of the patient's submerged weight, but no more than 20 g; a difference of the greatest load hydrogen content and the initial hydrogen content is calculated. If the difference after administering lactulose is 5 ppm or less, the absence of excessive hydrogen in the patient is diagnosed, and the laclose intolerance is suggested to be diagnosed by using other techniques. If the difference after administering lactulose falls within the range of 5 to 10 ppm, then the patient shows hydrogen production with the absence of the BOS. After making a pause of not less than 24 hours, the number of the load hydrogen contents is measured 30, 60, 90 and 120 min after the test load. The test solution is a lactose solution in a dose of 2 g per 1 kg of the patient's submerged weight, but no more than 50 g. That is followed by calculating a difference of the greatest load hydrogen content and the initial hydrogen content; if the difference after administering lactose is more than 10 ppm, the lactose intolerance is stated. If the difference after administering lactose is more than 10 ppm, the person being tested is stated to have hydrogen production with the presence of the BOS. After making a pause of not less than 24 hours, the number of the load hydrogen contents is measured 30, 60, 90 and 120 min after the test load. The test solution represents lactose in a dose of 2 g per 1 kg of the patient's submerged weight, but no more than 50 g. That is followed by calculating a 30^th-minute difference of the greatest load hydrogen content and the initial hydrogen content. If the difference after administering lactose is more than a threshold level of 10 ppm, the lactose intolerance is stated.

EFFECT: technique is non-invasive, enables additional detection of manifestations and symptoms of the carbohydrate intolerance of the person being tested on the second day, as well as the diagnosis of the presence or absence of the BOS that enables providing higher diagnostic reliability.

3 dwg, 3 ex