NEW PYRIMIDINE DERIVATIVES Russian patent published in 2014 - IPC C07D403/14 A61K31/506 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the derivatives of pyrimidine with formula I, where Z is a carbon atom or a nitrogen atom; Y is a carbon atom or a nitrogen atom, where one of the Z and Y is a nitrogen atom; A, D and E are chosen from the carbon atom and nitrogen atom; R¹ is hydrogen or methyl, when D is a carbon atom; R² is hydrogen or an amine group; R³ is hydrogen, methyl, trifluoromethyl or (C₀-C₁) alkylaryl; R⁵ is hydrogen or methyl; L-R⁴ is chosen from: and R⁶ is chosen from hydrogen and methyl; R⁷ is chosen from hydrogen, methyl, (C₁-C₄)alkyl-OH and (CO)OCH₃, R⁷a and R⁷b are independently chosen from hydrogen and methyl; R⁸ is chosen from halogen, hydrogen, hydroxy, (CO)OH, (CO)OCH₃, O(C₁-C₄) alkyl, O(C₁-C₄)alkyl(C₆-C₁₀)aryl, O(C₁-C₄)alkyl(C₂-C₉)heterocyclyl, O(EtO)_1-3(C₁-C₄)alkyl and OCF₃; and R¹¹ is chosen from hydrogen, methyl and O(C₁-C₄) alkyl. The invention also relates to a pharmaceutical formulation for curing of cancer which contains the compounds with the formula I, to the usage of the compounds with the formula I to produce a medicinal agent and pharmaceutical formulation and to the cancer curing method.

EFFECT: compounds with the formula I aimed at cancer curing.

20 cl, 3 tbl, 109 ex