FIELD: pharmacology.
SUBSTANCE: invention relates to pyrazolaminopyrimidine derivatives listed in claim 1 which are modulators of leucine-repeating kinase 2 (LRRK2), a pharmaceutical composition containing them, application of these compounds for treatment of diseases associated with the LRRK2 receptor such as Parkinson's disease, and to a method for Parkinson's disease treatment.
EFFECT: higher efficacy of compound application.
6 cl, 4 tbl, 52 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PYRAZOLAMINOPIRIMIDINE DERIVATIVES AS LEUCINE-REPEATING KINASE 2 (LRRK2) MODULATORS FOR TREATMENT OF PARKINSON DISEASE | 2013 |
|
RU2637948C2 |
| 2-(PHENYL OR PYRID-3-YL)AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF LEUCINE-RICH REPEATING KINASE 2 (LRRK2) FOR TREATMENT OF PARKINSON'S DISEASE | 2012 |
|
RU2647849C2 |
| HETEROCYCLIC PYRIMIDINE ANALOGUES AS TYK2 INHIBITORS | 2013 |
|
RU2641895C2 |
| FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2 | 2012 |
|
RU2650641C2 |
| BI-ARYL-META-PYRIMIDINE KINASE INHIBITORS | 2006 |
|
RU2589878C2 |
| BI-ARYL-META-PYRIMIDINE KINASE INHIBITORS | 2006 |
|
RU2597364C2 |
| AMINOPYRIDINE DERIVATIVES AS MODULATORS OF LEUCINE-RICH REPEATED KINASE 2 (LRRK2) | 2012 |
|
RU2634716C2 |
| INHIBITOR COMPOUNDS | 2013 |
|
RU2673079C2 |
| SUBSTITUTED N2-(4-AMINO-2-METHOXYPHENYL)-N4-[2-(DIMETHYLPHOSPHORYL)-PHENYL]-5-CHLORO-PYRIMIDINE-2,4-DIAMINES AS MODULATORS OF ALK AND EGFR, APPLICABLE FOR TREATING CANCER | 2015 |
|
RU2607371C1 |
| INHIBITOR OF EGFR AND PRODUCTION AND USE THEREOF | 2015 |
|
RU2702631C2 |
