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(19)

(11)

2 528 412

(13)

(51)

IPC

C07D403/04(2006-01-01)

C07D401/14(2006-01-01)

C07D405/14(2006-01-01)

C07D487/04(2006-01-01)

C07D491/56(2006-01-01)

A61K31/517(2006-01-01)

A61K31/519(2006-01-01)

A61P9/10(2006-01-01)

A61P3/10(2006-01-01)

A61P3/06(2006-01-01)

A61P43/00(2006-01-01)

(21) (22)

Application

2011137461/04, 2010-02-10

(24)

Start date

2010-02-10

(22)

Actual filing date

2010-02-10

(45)

Published

2014-09-20

(72)

Inventor

Bembenek Skott D.Khoukatt Frehnsis M.Leonard Barri Istman Ml.Rouzen Mark D.Tarantino Kajl T.Rabinovich Majkl Kh.Venkatesan Khirikharan

(73)

Holder

Janssen Farmatsevtika Nv

QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS Russian patent published in 2014 - IPC C07D403/04 C07D401/14 C07D405/14 C07D487/04 C07D491/56 A61K31/517 A61K31/519 A61P9/10 A61P3/10 A61P3/06 A61P43/00

Abstract RU 2528412 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to quinazolinone compounds of formula (I) and its pharmaceutically acceptable salts, wherein n is equal to 0 to 3, and R¹is defined as stated in the patent claim. The above compounds are prolyl hydroxylase inhibitors and can be used in pharmaceutical compositions and methods of treating pathological conditions, disorders and conditions mediated by prolyl hydroxylase activity.

EFFECT: compounds can be administered into the patient for treating, eg anaemia, vascular diseases, metabolic disorders, as well as for wound healing.

22 cl, 2 tbl, 211 ex

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RU 2 528 412 C2

Authors

Bembenek Skott D.

Khoukatt Frehnsis M.

Leonard Barri Istman Ml.

Rouzen Mark D.

Tarantino Kajl T.

Rabinovich Majkl Kh.

Venkatesan Khirikharan

Dates

2014-09-20—Published

2010-02-10—Filed