FIELD: organic chemistry.
SUBSTANCE: invention relates to bridge compounds of formula (I), while R2, R3, R4, R5 and R6 are defined in paragraph 1 of the claims. The invention also relates to specific bridging compounds.
EFFECT: modulation of MGL (monoacylglycerol lipase), useful in the treatment of disorders and conditions associated with MGL modulation, such as those associated with pain, mental disorders, neurological disorders (including, without limitation, major depressive disorder, treatment-resistant depression, anxiety depression, bipolar disorder), cancers and eye diseases.
58 cl, 4 tbl, 444 ex
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