NOVEL (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, METHOD OF OBTAINING THEREOF AND METHOD OF APPLICATION THEREOF IN THERAPY AS ANTI-CANCER MEDICATIONS Russian patent published in 2014 - IPC C07D493/04 A61K31/36 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to novel derivatives of epipodophyllotoxin, substituted in position 4 with possibly substituted chain of (poly)aminoalkylaminoalkylamide, or alkyl-urea, or alkyl-sulphonamide, of formula 1 where R represents hydrogen or C_1-4alkyl, A represents CO(CH₂)_n or CONH(CH₂)_n, where n equals 2, 3, 4 or 5, R1 represents H or C_1-4alkyl, R2 represents (CH₂)_m-NR3R4, where m equals 2, 3, 4 or 5, R3 represents H or C_1-4alkyl, R4 represents H, C_1-4alkyl or (CH₂)_p-NR5R6, where p equals 2, 3, 4 or 5, R5 represents H or C_1-4alkyl and R6 represents H, C₁-C₄alkyl or (CH₂)_q-NH₂, where q equals 2, 3, 4 or 5 or their pharmaceutically acceptable salts, as well as to methods of their obtaining and to their application as anti-cancer medication.

EFFECT: obtaining novel derivatives of epipodophyllotoxin.

11 cl, 19 ex