FIELD: medicine.
SUBSTANCE: invention refers to a new method for preparing anticancer preparations representing derivatives of (poly)aminoalkylaminoacetamide epipodofillotoxine of formula 1.
The method implies a condensation stage of the compounds of formulae 4 and 6 in a polar aprotonic solvent without pre-protection of functional amine groups to produce a compound of formula 1, wherein in formulae 1, 4 and 6 R represents hydrogen atom or -(CH2)c-NH2, 2≤a, b, c≤5.
EFFECT: what is offered is the new effective method for preparing the compounds with anticancer activity.
15 cl, 3 ex
Title |
Year |
Author |
Number |
NOVEL (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, METHOD OF OBTAINING THEREOF AND METHOD OF APPLICATION THEREOF IN THERAPY AS ANTI-CANCER MEDICATIONS |
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|
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|
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|
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|
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