FIELD: medicine.
SUBSTANCE: invention refers to a new method for preparing anticancer preparations representing derivatives of (poly)aminoalkylaminoacetamide epipodofillotoxine of formula 1. 
The method implies a condensation stage of the compounds of formulae 4 and 6 in a polar aprotonic solvent without pre-protection of functional amine groups to produce a compound of formula 1, wherein in formulae 1, 4 and 6 R represents hydrogen atom or -(CH2)c-NH2, 2≤a, b, c≤5.
EFFECT: what is offered is the new effective method for preparing the compounds with anticancer activity.
15 cl, 3 ex
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Year |
Author |
Number |
| NOVEL (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, METHOD OF OBTAINING THEREOF AND METHOD OF APPLICATION THEREOF IN THERAPY AS ANTI-CANCER MEDICATIONS |
2009 |
- Imber T'Erri
- Guminski Iv
- Barre Zhan-Mark
- Krjuzinski Anna
|
RU2529676C2 |
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1993 |
- Fajk-Eng Sum
- Ving Dzh.Li
- Rejmond T.Testa
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RU2123999C1 |
| NEW 7-(SUBSTITUTED)-8-(SUBSTITUTED)-9-[(SUBSTITUTED-GLYCYL)- -AMIDO]-6-DEMETHYL-6-DEOXYTETRACYCLINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR COMPLEXES WITH METALS, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ANTIBIOTIC ACTIVITY |
1993 |
- Fajk-Eng Sum
- Ving Dzh. Li
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- Rajmond T. Testa
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RU2125985C1 |
| CHROMONE DERIVATIVES, METHOD FOR PREPARING THEM AND THERAPEUTIC USES THEREOF |
2010 |
- Sokolof P'Er
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- Patuaso Zhan-Fransua
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RU2545214C2 |
| BENZO-N-HYDROXYAMIDE COMPOUNDS HAVING ANTI-TUMOR ACTIVITY |
2017 |
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- Modena, Daniela
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- Fossati, Gianluca
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| METHOD FOR PRODUCTION OF (3R, 3aS,6aR)-HEXAHYDROFURO[2,3-b]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1- BENZYL-2-HYDROXYPROPYLURETHANE |
2004 |
- Gojvaerts Nikolas Marta Feliks
- Vigerink Pit Tom Bert Pol'
- Zintser Kharmut Burgkhard
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| METHODS OF PRODUCING HEXAHYDROFURO[2, 3-b] FURAN-3-OL |
2007 |
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| BENZIMIDAZOLE DERIVATIVES, SYNTHESIS METHODS THEREOF, USE THEREOF AS FARNESOID X RECEPTOR (FXR) AGONIST AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES |
2007 |
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| 2,6-SUBSTUTED-4-MONOSUBSTITUTED AMINO-PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS |
2005 |
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RU2417990C2 |
