METHOD OF SYNTHESIS OF ANTICANCER DERIVATIVES OF (POLY)AMINOALKYLAMINOACETAMIDE EPIPODOFILLOTOXINE Russian patent published in 2012 - IPC C07D493/04 C07C211/00

Abstract RU 2450009 C2

FIELD: medicine.

SUBSTANCE: invention refers to a new method for preparing anticancer preparations representing derivatives of (poly)aminoalkylaminoacetamide epipodofillotoxine of formula 1. The method implies a condensation stage of the compounds of formulae 4 and 6 in a polar aprotonic solvent without pre-protection of functional amine groups to produce a compound of formula 1, wherein in formulae 1, 4 and 6 R represents hydrogen atom or -(CH₂)_c-NH₂, 2≤a, b, c≤5.

EFFECT: what is offered is the new effective method for preparing the compounds with anticancer activity.

15 cl, 3 ex

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RU 2 450 009 C2

Authors

Gjumehnski Iv

Grusso Mars'Jal'

Ehmber T'Erri

Dates

2012-05-10—Published

2008-09-23—Filed