PHARMACEUTICAL COMPOSITION OF POLYMER MICROPARTICLES WITH MODIFIED RELEASE KINETICS OF POORLY SOLUBLE DRUG SUBSTANCES Russian patent published in 2014 - IPC A61K9/14 A61K47/34 A61K31/34 A61K31/35 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine and describes a pharmaceutical composition of polymer microparticles with modified release kinetics of poorly soluble drug substances. The composition represents a mixture of polymer microparticles having a size of 1 to 100 mcm and consisting of a composite of a biodegradable and biocompatible polymer of poly-3-oxybutyrate or poly-3-oxybutyrate-with-3-oxyvalerate; an active drug substance having a water-solubility of less than 20 mcg/ml, particularly ivermectin; and an additive substance specified in phospholipids and/or polyethylene glycols, and/or poloxamers. The weight ratio of the additive substance to the polymer in the microparticles of the pharmaceutical composition profiles release kinetics of the active drug substance.

EFFECT: mixture of microparticles of various modifications enables additional variations of release kinetics of the active drug between the linear to degree nature, and a release rate.

18 cl, 3 tbl, 4 dwg