CONTROLLED RELEASE THERAPEUTIC AGENTS CONTAINING PEPTIDES Russian patent published in 2015 - IPC A61K9/16 A61K38/00 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine and can be used for producing a controlled-release therapeutic agent containing a modified biologically active agent encapsulated into a polymer, wherein the above modified biologically active agent represents a peptide having an amino acid sequence specified in a group consisting of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:9. What is also presented is providing the more effective charge of the biological agent, varying an erosion release rate of the biologically active agent, as well as varying the initial diffuse release of the biologically active agent in a polymer-based delivery system.

EFFECT: group of inventions enables changing release kinetics and/or parameters of the drug load of a peptide or a protein encapsulated in the polymer-based delivery systems through the direct variation of an isoelectric point and/or total charge of this peptide without changing the polymer charge.

13 cl, 10 dwg, 1 tbl, 2 ex