FIELD: medicine.
SUBSTANCE: there are presented versions of a method for a penetrant delivery involving creating a number of delivery openings. An opening depth makes from approximately 40 to approximately 90 micron. The above delivery openings are characterised by a distribution resultant in a normal distribution curve. There are also presented versions of a method for assessing the effectiveness of the penetrant delivery through a biological membrane, involving measuring the fixed penetrant concentration, measuring a transepidermal water loss through a mammalian membrane and comparing the measurement results to the known values for each providing the desired results.
EFFECT: inventions provide the optimum percutaneous substance delivery to the body by determining the optimum depth range of the delivery openings providing the effective absorption of the therapeutic substances.
25 cl, 10 tbl, 9 dwg, 5 ex
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