OXIDISED LIPID COMPOUNDS AND THEIR APPLICATION Russian patent published in 2014 - IPC C07C59/125 C07F9/09 C07C59/10 A61K31/683 A61K31/685 A61K31/19 A61P29/00 

FIELD: chemistry.

SUBSTANCE: in formula (I) each of A₁, A₂ and A₃ is independently selected from the group, consisting of O and S, R₁ represents an alkyl chain with the length of 2-28 carbon atoms, R₂ is selected from the group, consisting of (3-carboxy)propyl and (20carboxy)ethyl, and R₃ is selected from the group, consisting of H, C_1-20acyl, phosphate, phosphocholine, phosphoethanolamine, phosphoethanolamine-N-glutaric acid and phosphoserine. The invention also relates to a pharmaceutical composition, containing the said compounds, and to the application of the compounds for manufacturing a medication, intended for treatment or prevention of diseases or disorders, associated with inflammation, or for the reduction of the level of cytokine, selected from the group, consisting of interleukin-12 and interleukin-23.

EFFECT: increase of the treatment efficiency.

60 cl, 39 dwg, 18 ex