METHOD FOR OBTAINING SUPRAMOLECULAR PLATINUM COMPOUNDS Russian patent published in 2023 - IPC C07F15/00 C07J41/00 A61K9/14 A61K31/282 A61K47/50 A61K47/54 A61P35/00 

FIELD: nanotechnology; anticancer drugs.

SUBSTANCE: invention relates to a method for producing a lipid-conjugated platinum compound. The method includes the following: reacting a water-soluble lipid salt with a water-soluble platinum compound in a substantially aqueous solution to produce a lipid-conjugated platinum compound as a precipitate, wherein the water-soluble lipid salt contains a compound of formula II, where X is NH or N-CH₂COO^-, X₁ is selected from the group consisting of -(CH₂)_nO-, -(CH₂)_nNHCOO-, -(CH₂)_nCONH(CH₂)_nO-, -(CH₂)_nO(CH₂)_nO-, -(CH₂)_nC(O)-, -(CH₂)_nNHCO(CH₂)_nO- and -(CH₂)_nCOO-, n is 0–2. Preparation of the water-soluble lipid salt of formula II consists of: a. covalent connection of the linker with the lipid of formula II; and b. reaction of a linker covalently attached to a lipid with a base, which is LiOH, NaOH, KOH, RbOH, CsOH, Mg(OH)₂, Ca(OH)₂, Sr(OH)₂, Ba(OH)₂, with an acid, such as trifluoroacetic acid (TFA), or any combination thereof. A method for producing nanoparticles and compositions for use in chemotherapy are also proposed.

EFFECT: proposed method provides >50% yield and >70% purity for the lipid-conjugated platinum compound.

44 cl, 30 dwg, 22 tbl, 13 ex

Lipid
(Formula II)