LIPID COMPOUND AND COMPOSITION BASED THEREON Russian patent published in 2024 - IPC C07C229/12 C07C229/16 C07C237/10 C07D249/04 C07D295/88 C07D401/06 C07D413/06 A61K9/51 A61P9/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of the following formula (II) or formula (III), or a compound which is one of A7, A9, A10, A12, A15, A20, A21, A22, A23, A24, A27, A30, A31, A32 and A48.In formulas (II) and (III) R₁ is selected from -R₁’-X, R₁’ represents -(CH₂)_0-6- and X is hydroxyl, C(O)O(CH₂)_1-3NR_aR_b, -C(O)NH(CH₂)_1-3NR_aR_b, NHC(O)(CH₂)_1-3NR_aR_b, -NHC(O)CH(NR_aR_b)(CH₂)_1-3NR_aR_b or 5–6-membered heteroaryl containing 1–3 heteroatoms independently selected from N, wherein said heteroaryl optionally substituted with the following groups: -(CH₂)_1-3OH, -(CH₂)_1-3NR_aR_b and -(CH₂)_1-3C(O)NR_aR_b; or X can also be or R_a and R_b are independently selected from H, C_1-3-alkyl, -(CH₂)_1-3NH₂ and (CH₂)_1-3NH(CH₂)_1-3NH₂; or R_a and R_b together with the nitrogen atom to which they are attached form 5–10-membered heterocycle, which includes 1–3 heteroatoms selected from N or O, wherein said heterocycle is optionally substituted with C_1-6alkylhydroxyl; each M is independently selected from C(O)O- or -C(O)NH-; each R' is independently selected from C_1-10-alkyl or C_3-12-alkenyl; each R* is independently selected from C_1-10-alkyl; n and m are independently selected from an integer in range from 1 to 9. Invention also relates to compositions containing said ionisable lipid compound and a method of producing a lipid nanoparticle based thereon.

EFFECT: compounds can be used in compositions for administering pharmaceutical preparations based on nucleic acids, such as mRNA and siRNA.

41 cl, 5 dwg, 10 tbl, 45 ex