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2 665 841

(13)

(51)

IPC

A61K39/95(2006-01-01)

C07K14/22(2006-01-01)

C07K16/12(2006-01-01)

(21) (22)

Application

2014136401, 2013-03-06

(24)

Start date

2013-03-06

(22)

Actual filing date

2013-03-06

(45)

Published

2018-09-04

(72)

Inventor

Anderson Annaliza SibilKhojset Syuzan KejDzhensen Ketrin YuteMoran Dzhastin KejtRappen Mark E.

(73)

Holder

Pfajzer Ink.

NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS OF USE THEREOF Russian patent published in 2018 - IPC A61K39/95 C07K14/22 C07K16/12

Abstract RU 2665841 C2

FIELD: medicine.

SUBSTANCE: recombinant polypeptide is proposed for inducing an immune response against Neisseria meningitidis in a mammal, an immunogenic composition comprising it, and a recombinant nucleic acid encoding said polypeptide. Recombinant polypeptide consists of the amino acid sequence shown in SEQ ID NO: 71, wherein the first twenty amino acid residues of the sequence do not contain cysteine. Immunogenic composition for inducing an immune response against Neisseria meningitidis in a mammal includes an effective amount of said polypeptide and a pharmaceutically acceptable carrier.

EFFECT: expression level of said recombinant polypeptide is greater than the expression level of the corresponding non-mute type of the sequence of SEQ ID NO: 70.

15 cl, 9 dwg, 34 tbl, 23 ex

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RU 2 665 841 C2

Authors

Anderson Annaliza Sibil

Khojset Syuzan Kej

Dzhensen Ketrin Yute

Moran Dzhastin Kejt

Rappen Mark E.

Dates

2018-09-04—Published

2013-03-06—Filed