CREAM FOR MEDICAL APPLICATION CONTAINING FUSIDIC ACID PREPARED WITH USING SODIUM FUSIDATE AND CONTAINING BIOPOLYMER, AND METHOD FOR PREPARING IT Russian patent published in 2014 - IPC A61K9/06 A61K31/575 A61P17/00 A61P31/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to the pharmaceutical industry and represents a cream for medical application for local treatment of bacterial infections and for wound healing, which contains fusidic acid in an amount of 0.1 wt % to 25 wt % and a biopolymer, preferentially chitosan; fusidic acid is formed in situ in an oxygen-free medium; the above cream contains fusidic acid formed in situ by transforming sodium fusidate at adding the acid slowly, with a particle size of an active agent of the substance of 2.33 mcm to 16.3 mcm, while the biopolymer is introduced into a cream base containing at least one ingredient of each type: primary and secondary emulsifying agents specified in a group containing ketostearyl alcohol, ketomacrogol-1000, polysorbate-80, Span-80, paraffin as a wax product, a combined solvent specified in a group containing propylene glycol, hexylene glycol, polyethylene glycol-400, nitric acid or lactic acid and water.

EFFECT: invention provides the high stability of the active ingredient during the whole shelf life.

12 cl, 18 tbl, 2 dwg