FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (IIB) or a pharmaceutically acceptable salt thereof, where E denotes -CH2-; Q is -CH2-; Z is hydrogen; V is N; R12 denotes hydrogen; R15 denotes a difluoromethoxy group; R16 denotes hydrogen; R21 denotes piperidinyl, piperazinyl or morpholinyl, any of these groups may optionally contain one substitute selected from a group comprising C1-C6-alkylsulfonyl, oxo group and carboxy group; and R23 denotes hydrogen. Invention also relates to a pharmaceutical composition based on a compound of formula (IIB), use thereof and a method of treating and/or preventing rheumatoid arthritis or Crohn's disease.
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EFFECT: technical result is obtaining novel heterocyclic compounds possessing properties of TNFα activity modulator.
6 cl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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RU2685234C1 |
| IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | 2014 |
|
RU2678305C1 |
