FIELD: medicine.
SUBSTANCE: invention relates to field of biotechnology. Disclosed are methods and technologies of hepatitis C virus neutralisation, as well as antibodies against hepatitis C virus. It is suggested to apply completely human homogeneous antibodies RYB1, RYB2 and RYB3, as well as compositions on their base for prevention and treatment of hepatitis C. Said antibodies are obtained by cultivation by hybrid BIONA-RYB1, BIONA-RYB2 and BIONA-RYB3. Efficiency of antibodies is conditioned by the fact that they bind epitopes, respectively, E1, E2, E3 of protein E2 of hepatitis C virus envelope. Neutralising activity of antibodies on modal system of human cells infection in culture is demonstrated. It is shown that application of claimed group of inventions makes it possible to increase reliability of binding hepatitis C virus by antibodies.
EFFECT: claimed group of inventions can be applied in medicine, pharmaceutical industry and close fields of science and technique.
9 cl, 9 dwg, 8 tbl, 13 ex
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