KIT FOR GIVING PRELIMINARY ACTION DIRECTION, METHOD AND AIDS USED THEREIN Russian patent published in 2015 - IPC A61K47/48 A61K51/04 A61K101/00 A61K103/00 

FIELD: medicine.

SUBSTANCE: group of inventions refers to a kit for targeted medical imaging and/or clinical medicine, and to a method for using the kit. The declared kit comprises a pre-guide probe and an effector probe, wherein the pre-guide probe comprises a primary guide fragment and a first bio-orthogonal reactive group, and wherein the effector probe comprises an effector element, such as a label or a pharmaceutically active compound, and a second bio-orthogonal reactive group. Any of the first and second bio-orthogonal reactive groups represents dienophile in the form of stressed 8-merous cycle (cyclooctene or cyclooctine), while diene represents electron-deficient tetrazine or other applicable diene. A method for using the kit involves administering the pre-guide probe into the individual and enabling the probe circulating in the individual system for a period of time effective to achieve binding of the primary guide fragment with the primary target with the unbounded substance discharge from the body, with the effector probe to be inserted.

EFFECT: invention involves using the [4+2] Diels-Alder retrochemical reaction with electron reuptake to bind the pre-guide probe and the effector probe that enables fast in vivo reaction behaviour.

12 cl, 12 dwg, 1 tbl, 3 ex