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(19)

(11)

2 402 548

(13)

(51)

IPC

C07D403/14(2006-01-01)

C07D405/14(2006-01-01)

C07D417/14(2006-01-01)

A61K31/40(2006-01-01)

A61K49/18(2006-01-01)

A61K49/06(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2006144958/04, 2005-05-19

(24)

Start date

2005-05-19

(22)

Actual filing date

2005-05-19

(45)

Published

2010-10-27

(72)

Inventor

Bojd SharonChehn' LjanGangvar SandzhivGerlaveh VinsenKhorgan KilianLi Chzhi-KhunSufi Bilal

(73)

Holder

Medareks, Ink.

CHEMICAL LINKERS AND CONJUGATES THEREOF Russian patent published in 2010 - IPC C07D403/14 C07D405/14 C07D417/14 A61K31/40 A61K49/18 A61K49/06 A61P35/00

Abstract RU 2402548 C2

FIELD: chemistry.

SUBSTANCE: medicine-ligand conjugates are powerful cytotoxins in which the medicine is bonded to the ligand through a peptide, hydrazine or disulphide linker.

EFFECT: agents are highly effective.

63 cl, 8 ex

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RU 2 402 548 C2

Authors

Bojd Sharon

Chehn' Ljan

Gangvar Sandzhiv

Gerlaveh Vinsen

Khorgan Kilian

Li Chzhi-Khun

Sufi Bilal

Dates

2010-10-27—Published

2005-05-19—Filed