Show metadata Hide metadata

(19)

(11)

2 540 070

(13)

(51)

IPC

C07D213/18(2006-01-01)

A61K31/4412(2006-01-01)

A61P9/10(2006-01-01)

A61P3/06(2006-01-01)

(21) (22)

Application

2013153875/04, 2013-12-05

(24)

Start date

2013-12-05

(22)

Actual filing date

2013-12-05

(45)

Published

2015-01-27

(72)

Inventor

Gomzhin Andrej MikhajlovichGermanov Sergej BorisovichZykova Ol'Ga Valer'EvichFilippova Elizaveta SergeevnaGermanova Ol'Ga Leonidovna

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennost'Ju

2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE DICHLOROACETATE, ITS STABLE CRYSTALLINE FORM AND METHOD OF OBTAINING THEREOF Russian patent published in 2015 - IPC C07D213/18 A61K31/4412 A61P9/10 A61P3/06

Abstract RU 2540070 C1

FIELD: chemistry.

SUBSTANCE: invention relates to novel substance - 2-ethyl-6-methyl-3-hydroxypyridine dichloroacetate of formula I its stable crystalline form and method of obtaining thereof. Substance (I) possesses antiatherosclerotic, hypolipidemic, antihypoxic, nootropic, anxiolytic and adaptogenic action with low toxicity (LD₅₀=30000 mg/kg, rats, intragastrically) and absence of hygroscopicity. Substance is obtained with interaction of equimolar quantities of 2-ethyl-6-methyl-3-hydroxypyridine and dichloroacetic acid in presence of solvent.

EFFECT: increase of stability.

9 cl, 8 dwg, 10 tbl, 12 ex

Similar patents RU2540070C1

Title	Year	Author	Number
COMPLEX OF 3-(2,2,2-TRIMETHYLHYDRAZINIUM)PROPIONATE-2-ETHYL-6-METHYL-3-HYDROXYPYRIDINIUM DISUCCINATE POSSESSING ANTIHYPOXIC AND ADAPTOGENIC ACTION, AND METHOD FOR PREPARING IT	2012	Engashev Sergej Vladimirovich Germanov Sergej Borisovich Mel'Nichenko Vladimir Ivanovich	RU2485953C1
ASPIRINATE-2-ETHYL-6-METHYL-3-HYDROXIPIRIDINE THAT IS ANTOHYPOXIC AND WAY OF ITS PRODUCTION	2010	Gomzhin Andrej Mikhajlovich Germanov Sergej Borisovich Germanova Ol'Ga Leonidovna Filippova Elizaveta Sergeevna	RU2442774C1
DERIVATIVE OF 3-HYDROXYPYRIDINE WITH ANXIOLYTIC AND NOOTROPIC EFFECT	2017	Bogomolova Olga Alekseevna Demidova Marina Aleksandrovna Skachilova Sofiya Yakovlevna	RU2664453C1
NOOTROPIC AGENT POSSESSING ANTI-HYPOXIC ACTIVITY	2006	Shilova Inessa Vladimirovna Suslov Nikolaj Innokent'Evich Slepushkina Ol'Ga Pavlovna Kuvacheva Natal'Ja Valer'Evna Provalova Nadezhda Valer'Evna	RU2314115C1
2-[2-(DIETHYLAMINO) -ETHYLTHIO]-5,6- DIMETHYLBENZIMIDAZOLE SALTS SHOWING ANTIISCHEMIC, ANTIHYPOXIC AND ANTIARRHYTHMIC ACTIVITY AND 2-[2-(DIETHYLAMINO) -ETHYLTHIO]-5,6- DIMETHYLBENZIMIDAZOLE AS AN INTERMEDIATE PRODUCT FOR SYNTHESIS OF 2-[2-(DIETHYLAMINO) -ETHYLTHIO] -5,6-DIMETHYLBENZIMIDAZOLE SALTS	1991	Savel'Ev V.L. Mozhaeva T.Ja. Chichkanov G.G. Tsorin I.B. Kirsanova G.Ju. Kazanova G.V. Luk'Janova L.D. Chernobaeva G.N. Romanova V.E. Germanova Eh.L. Kaverina N.V. Berdjaev S.Ju. Olenina N.G.	RU2027709C1
3-(N,N-DIMETHYLCARBAMOYLHYDROXY)-2-ETHYL-6-METHYLPYRIDINE SUCCINATE SHOWING ANTIHYPOXIC ACTIVITY	1993	Glushkov R.G. Dronova L.N. Mashkovskij M.D. Gus'Kova T.A. Luk'Janova L.D. Romanova V.E. Chernobaeva G.N. Germanova Eh.L.	RU2095350C1
COMPLEX SUBSTITUTED IMIDAZOLE COMPOUNDS HAVING ANTIDOTE AND ANTIHYPOXANTHIC ACTIVITIES	1995	Skushnikova A.I. Domnina E.S. Titunov L.A. Chumakov V.V. Barinov V.A. Borodavko V.K.	RU2115653C1
MEDICATION POSSESSING HAEMOSTIMULATING, ANTIMUTAGENIC, ANTITUMOUR, CEREBROPROTECTIVE, ANTIHYPOXIC, NOOTROPIC, ANXIOLYTIC AND ANTINEUROTIC ACTION	2010	Dygaj Aleksandr Mikhajlovich Suslov Nikolaj Innokent'Evich Zjuz'Kov Gleb Nikolaevich Kuzovkina Inna Nikolaevna Zhdanov Vadim Vadimovich Udut Elena Vladimirovna Guseva Anastasija Viktorovna Vdovitchenko Marija Jur'Evna Shilova Inessa Vladimirovna Smirnov Vjacheslav Jur'Evich Churin Aleksej Aleksandrovich Voronova Ol'Ga Leonidovna Simanina Elena Vladislavovna Neupokoeva Oksana Vladimirovna Fedorova Elena Pavlovna	RU2438691C1
PHOSPHINIC ACID ESTERS OR THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION BASED ON ABOVE COMPOUNDS, AND METHOD FOR CORRECTION OF DISTURBANCES IN METABOLIC PROCESSES IN BRAIN	1994	Tarasova R.I. Semina I.I. Pavlov V.A. Moskva V.V.	RU2141961C1
DISODIUM SALT OF 3-HYDROXYHIPPURIC ACID, HAVING ANTIHYPOXIC AND CEREBROPROTECTIVE ACTION	2014	Brel' Anatolij Kuz'Mich Tjurenkov Ivan Nikolaevich Lisina Svetlana Viktorovna Budaeva Julija Nikolaevna Rodina Natal'Ja Valentinovna Volotova Elena Vladimirovna Kurkin Denis Vladimirovich Bakulin Dmitrij Aleksandrovich	RU2559875C1

RU 2 540 070 C1

Authors

Gomzhin Andrej Mikhajlovich

Germanov Sergej Borisovich

Zykova Ol'Ga Valer'Evich

Filippova Elizaveta Sergeevna

Germanova Ol'Ga Leonidovna

Dates

2015-01-27—Published

2013-12-05—Filed