FIELD: chemistry.
SUBSTANCE: presented is a group of inventions containing a solid dosage composition and a method for producing it. The solid dosage composition contains at least one pressed layer containing ibuprofen, microcrystalline cellulose and hydroxypropyl methylcellulose (HPMC) K100LV, HPMC K4M and combinations thereof, wherein HPMC is present in an amount of 10 to 30 wt % of the pressed layer, wherein viscosity of 2 wt/wt % of K100LV, HPMC K4M and a combination thereof makes 100 to 1414 sP, and wherein ibuprofen is subject to wet granulation. The method for producing the above composition involves pre-mixing ibuprofen by wet granulation with the above ingredients.
EFFECT: minimising the immediate release of ibuprofen ensured by producing the more stable gel matrix.
3 cl, 9 dwg, 2 tbl, 24 ex
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