SODIUM IBUPROFEN TABLETS AND METHODS FOR PREPARING PHARMACEUTICAL COMPOSITIONS CONTAINING SODIUM IBUPROFEN Russian patent published in 2020 - IPC A61K31/192 A61K47/38 A61K47/26 A61K47/20 A61K47/04 A61K9/20 A61K9/30 A61J3/10 A61P29/02 A61P19/02 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: described is a pharmaceutical composition of ibuprofen sodium in the form of a tablet or caplets. Pharmaceutical composition contains a core consisting of a) granules consisting of dihydrate of sodium ibuprofen, mannitol and a sliding substance. Weight ratio of mannitol to dihydrate of ibuprofen sodium makes 1:3.9 or 1:4.3. Said granules are pressed together b) with a mixture of mannitol, microcrystalline cellulose, a lubricant and a sliding substance. Weight ratio of mannitol to microcrystalline cellulose is 1:1, 1.6:1 or 3:1. Components (a) and (b) are present in weight ratio of 2.6:1 or 3:1, respectively. Ratio of total sodium content in said pharmaceutical composition to ibuprofen is less than 7:60. Pharmaceutical composition can contain at least one pharmaceutically acceptable shell. What is also described is a method for preparing a pharmaceutical composition.

EFFECT: pharmaceutical composition in the form of a tablet with low sodium content is characterized by improved stability, high strength and high bioavailability of ibuprofen.

13 cl, 16 dwg, 17 tbl, 10 ex