NITROIMIDAZOXAZINES AND USING THEM IN TUBERCULOSIS TREATMENT Russian patent published in 2015 - IPC C07D498/04 A61K31/5365 A61K31/06 A61P31/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to organic chemistry, namely to nitroimidazoxazine derivatives of formula , wherein X represents O, OCH₂, OCH₂CH=CH or OCH₂C≡C; Y represents a group of any of formulas IIa-IIc, wherein means an attachment point to X, and Z in formulas

represents CH₂, CH=CH, C≡C or a direct bond; the numbers 2, 3 and 4 are positions of a terminal ring having R₁ as a substitute; the terminal ring of formula I comprises C, CH or one nitrogen atom in each position, and each of R₁ and R₂ in formulas I and IIa represents one or two substitutes found in any accessible position of the ring and independently represents H, F, Cl, CF₃, OCF₂H, OCF₃ or combinations thereof. Besides, the invention refers to a pharmaceutical compound based on a compound of formula I, a method of treating a microbial infection, specific compounds.

EFFECT: there are prepared new compound effective in treating the microbial infections, including in treating the diseases caused by Mycobacterium tuberculosis.

8 cl, 28 dwg, 3 tbl, 3 ex