NITROIMIDAZOOXAZINE AND NITROIMIDAZOOXAZOLE ANALOGUES AND USE THEREOF Russian patent published in 2015 - IPC C07D498/04 A61K31/424 A61K31/4439 A61K31/506 A61K31/497 A61K31/5365 A61P31/06 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to nitroimidazooxazine derivatives of general formula I, where n equals 1, V and W independently denote H or CH₃, and one of X and Y is H and the other is one of the formulae and , where formula IIa includes a single ring labelled at position 3 and position 4 and containing R₁ as a substitute, and formula IIb includes a first ring labelled at position 3 and position 4 and containing as substitutes both R₂ and a terminal ring, labelled at position 4 and containing R₁ as a substitute, where the single ring of formula IIa and the first ring and the terminal ring of formula IIb include C, CH, or N at each ring position, where the single ring of formula IIa and the first ring and the terminal ring of formula IIb independently contain no more than two nitrogen atoms; Z in formulae IIa and IIb is CH₂ or a direct bond, R₁ is independently any one or two of H, F, C1, CF₃, OCF₃ or OCH₂Ph, and R₂ is H. The invention also relates to a pharmaceutical composition based on the compound of formula I, a method of preventing and treating a microbial infection based on use of the compound of formula , and specific nitroimidazooxazine derivatives.

EFFECT: obtaining novel compounds with useful biological activity.

7 cl, 21 dwg, 3 tbl