HETEROCYCLIC MUSCARINIC AGONISTS AND COMPOSITIONS, THEIR USING AND METHODS FOR TREATMENT Russian patent published in 2007 - IPC C07D451/02 C07D417/06 C07D413/06 C07D401/06 A61K31/435 A61P25/00 A61P43/00 

FIELD: organic chemistry, medicine.

SUBSTANCE: invention describes a compound of the formula (I):

wherein R¹ is chosen from the following group: (C₁-C₆)-alkyl, (C₂-C₆)-alkylidene, (C₂-C₆)-alkenyl, (C₂-C₆)-alkynyl, -O-(C₁-C₆)-alkyl, -O-(C₂-C₆)-alkenyl; m = 1; C₃-C₄ mean -CH₂-CH or -CH=C, or C₄ represents -CH and C₃ absents; R² and R³ represent hydrogen atom (H); or R², R³, m and C₃-C₄ form compound of the formula:

; each among R⁴ and R⁵ is chosen independently from group comprising H, halogen atom, hydroxy-group, (C₁-C₆)-alkyl, -O-(C₁-C₆)-alkyl; L¹ and L² represent biradicals chosen from group comprising -(CR⁶)=C(R⁷), -C(R⁶)=N and -N=C(R⁶)-, -S-; Y is chosen from group consisting of oxygen atom (O) and two hydrogen atoms; X is chosen from group comprising -C(R⁶)(R⁷)-C(R⁶)(R⁷)-, -C(R⁶)=C(R⁷)-, -O-C(R⁶)(R⁷)-, -C(R⁶)(R⁷-O-, -S-C(R⁶)(R⁷)-, -C(R⁶)(R⁷)-S- and -S-. Invention describes compositions comprising compounds of the formula (I), method for enhancing activity of muscarinic receptors of subtype M1, method for treatment of diseases associated with muscarinic receptors.

EFFECT: valuable medicinal properties of compounds and composition.

14 cl, 2 ex