HIGH-AFFINITY HUMAN ANGIOPOIETIN-2 ANTIBODIES Russian patent published in 2015 - IPC C07K16/22 A61K39/395 A61P35/00 A61P27/02 A61P13/12 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to biotechnology. What is presented is a recovered human antibody or its antigen-binding fragment, which specifically binds to human angiopoietin-2 (hAng-2), but does not substantially binds to hAng-1 characterised by the presence of CDR variable heavy and light chain domains. What is described is a pharmaceutical composition on the basis of a therapeutically effective amount of the antibody. Disclosed are: variants of the recovered antibody or its antigen-binding fragment in producing drug preparation for treating a patient suffering various diseases including a tumour. Described are the versions of the methods of treating various diseases.

EFFECT: using this invention provides the antibody highly specific to human angiopoietin-2 (hAng-2) with an affinity constant of approximately 10^-11, which does not substantially bind to hAng-1, that can find application in treating various diseases related to hAng-2 hyperactivity.

19 cl, 35 tbl, 3 dwg, 13 ex