Patenton — panteon of patents

(19)

RU

(11)

2 640 253

(13)

C2

(51)

IPC

A61K39/395(2006-01-01)

C07K16/22(2006-01-01)

C07K16/46(2006-01-01)

A61P35/00(2006-01-01)

A61P9/00(2006-01-01)

C12N15/82(2006-01-01)

(21) (22)

Application

2014149553, 2014-12-09

(24)

Start date

2009-10-07

(22)

Actual filing date

2014-12-09

(45)

Published

2017-12-27

(72)

Inventor

Bener MonikaBrinkmann UlrikhZhorzh GiGriep Remko-AlbertImkhof-Yung ZabineKavle AnitaKettenberger KhubertKlajn KristianRegula Jerg TomasShefer VolfgangShantser Yurgen MikhaelShojer VernerZeeber ShtefanTomas Markus

(73)

Holder

F.Khoffmann-Lya Rosh Ag

BISPECIFIC ANTI-VEGF/ANTI-ANG-2 ANTIBODIES Russian patent published in 2017 - IPC A61K39/395 C07K16/22 C07K16/46 A61P35/00 A61P9/00 C12N15/82 

Abstract RU 2640253 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to a bispecific antibody specifically binding to a human vascular endothelial growth factor-VEGF and human angiopoietin-2-ANG-2, a pharmaceutical composition containing it, as well as a method for its preparation. Also a nucleic acid encoding the above antibody and a vector or host cell containing the aforementioned nucleic acid are disclosed.

EFFECT: invention allows effective treatment of cancer and/or vascular diseases.

12 cl, 19 dwg, 18 tbl, 20 ex

Similar patents RU2640253C2

Title Year Author Number
BISPECIFIC ANTI-VEGF/ANTI-ANG-2 ANTIBODIES 2009
  • Monika Behner
  • Ul'Rikh Brinkmann
  • Gi Zhorzh
  • Remko-Al'Bert Griep
  • Zabine Imkhof-Jung
  • Anita Kavl'E
  • Khubert Kettenberger
  • Kristian Klajn
  • Jerg Tomas Regula
  • Vol'Fgang Shehfer
  • Jurgen Mikhaehl' Shantser
  • Verner Shojer
  • Shtefan Zeeber
  • Markus Tomas
 RU2542382C2
BISPECIFIC BIVALENT ANTI-VEGF/ANTI-ANG-2 ANTIBODIES 2011
  • Bener Monika
  • Imkhof-Yung Zabine
  • Kavle Anita
  • Kettenberger Gubert
  • Klyajn Kristian
  • Regula Jorg Tomas
  • Shefer Volfgang
  • Shantser Jyurgen Mikhel
  • Shojer Verner
  • Shtubenraukh Kaj-Gunnar
  • Tomas Markus
 RU2597973C2
ANTIBODIES AGAINST HUMAN ANGIOPOIETIN-2 2009
  • Brinkmann Ul'Rikh
  • Grip Remko-Albert
  • Kalutsa Klaus
  • Kavl'E Anita
  • Klajn Kristian
  • Regula Jerg Tomas
  • Shojer Verner
 RU2569461C2
ANTIBODIES AGAINST HUMAN ANGIOPOIETIN-2 2009
  • Ul'Rikh Brinkmann
  • Remko-Albert Grip
  • Klaus Kalutsa
  • Anita Kavl'E
  • Kristian Klajn
  • Jerg Tomas Regula
  • Verner Shojer
 RU2569107C2
BISPECIFIC ANTIGEN-BINDING PROTEINS 2010
  • Zabine Imkhof-Jung
  • Kristian Klajn
  • Jerg Tomas Regula
  • Vol'Fgang Shehfer
  • Jurgen Mikhaehl' Shantser
 RU2573914C2
TRI- OR TETRASPECIFIC ANTIBODIES 2010
  • Rebekka Krosdejl
  • Kristian Klajn
  • Vol'Fgang Shehfer
  • Jurgen Mikhaehl' Shantser
 RU2570633C2
BISPECIFIC, TETRAVALENT ANTIGEN BINDING PROTEINS 2010
  • Zabine Imkhof-Jung
  • Kristian Klajn
  • Jerg Tomas Regula
  • Volfgang Shefer
  • Jurgen Mikhael Shantser
 RU2604189C2
BISPECIFIC ANTIBODIES 2011
  • Brinkmann Ul'Rikh
  • Kroasdale Rebekka
  • Djurr Kharal'D
  • Kljajn Kristian
  • Kopetski Ehrkhard
  • Lau Vil'Ma
  • Regula Jorg Tomas
  • Shantser Jjurgen Mikhel'
  • Umana Pablo
  • Varta Katarina
 RU2573588C2
VARIANTS OF Fc-REGION WITH IMPROVED ABILITY TO BIND TO PROTEIN A 2015
  • Shlotauer Tilman
 RU2698969C2
COMPOSITION CONTAINING ANTIBODY 2019
  • Freichel Christian
  • Mueller Claudia
  • Mueller Robert
  • Szczesny Piotr Jan
  • Worgull Martin
  • Wurth Christine
 RU2806628C2

RU 2 640 253 C2

Authors

Bener Monika

Brinkmann Ulrikh

Zhorzh Gi

Griep Remko-Albert

Imkhof-Yung Zabine

Kavle Anita

Kettenberger Khubert

Klajn Kristian

Regula Jerg Tomas

Shefer Volfgang

Shantser Yurgen Mikhael

Shojer Verner

Zeeber Shtefan

Tomas Markus

Dates

2017-12-27—Published

2014-12-09—Filed

download Download PDF read Similar patents