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2 640 253

(13)

(51)

IPC

A61K39/395(2006-01-01)

C07K16/22(2006-01-01)

C07K16/46(2006-01-01)

A61P35/00(2006-01-01)

A61P9/00(2006-01-01)

C12N15/82(2006-01-01)

(21) (22)

Application

2014149553, 2014-12-09

(24)

Start date

2009-10-07

(22)

Actual filing date

2014-12-09

(45)

Published

2017-12-27

(72)

Inventor

Bener MonikaBrinkmann UlrikhZhorzh GiGriep Remko-AlbertImkhof-Yung ZabineKavle AnitaKettenberger KhubertKlajn KristianRegula Jerg TomasShefer VolfgangShantser Yurgen MikhaelShojer VernerZeeber ShtefanTomas Markus

(73)

Holder

F.Khoffmann-Lya Rosh Ag

BISPECIFIC ANTI-VEGF/ANTI-ANG-2 ANTIBODIES Russian patent published in 2017 - IPC A61K39/395 C07K16/22 C07K16/46 A61P35/00 A61P9/00 C12N15/82

Abstract RU 2640253 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to a bispecific antibody specifically binding to a human vascular endothelial growth factor-VEGF and human angiopoietin-2-ANG-2, a pharmaceutical composition containing it, as well as a method for its preparation. Also a nucleic acid encoding the above antibody and a vector or host cell containing the aforementioned nucleic acid are disclosed.

EFFECT: invention allows effective treatment of cancer and/or vascular diseases.

12 cl, 19 dwg, 18 tbl, 20 ex

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RU 2 640 253 C2

Authors

Bener Monika

Brinkmann Ulrikh

Zhorzh Gi

Griep Remko-Albert

Imkhof-Yung Zabine

Kavle Anita

Kettenberger Khubert

Klajn Kristian

Regula Jerg Tomas

Shefer Volfgang

Shantser Yurgen Mikhael

Shojer Verner

Zeeber Shtefan

Tomas Markus

Dates

2017-12-27—Published

2014-12-09—Filed