METHOD FOR ENTERO- AND PANCREACTOPROTECTIVE ACTION OF NON-STEROID ANTI-INFLAMMATORY PREPARATIONS Russian patent published in 2015 - IPC G09B23/28 A61K31/18 A61P29/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to experimental medicine and gastroenterology, and can be used for the entero- and pancreatoprotective action of non-steroid anti-inflammatory preparations in simulating the gastric ulcer and/or pancreatitis experimentally. To this effect, the simulation is preceded by administering courses of Ketanov, Celebrex or Ketonal. The preparations are administered parenterally. A dose for the first three days is 2.5-3.1 mg/kg. A dose for the following three days is 1.5-2.4 mg/kg. That is followed by four days in a dose of 0.5-1.4 mg/kg with the therapeutic course repeated 1.5-2 months later. For the first three days of the repeated course, a dose of the preparation makes 0.7-2.0 mg/kg. A dose for the following three days makes 2.1-2.6 mg/kg. And for the final four days, a dose of the preparation makes 2.7-3.1 mg/kg.

EFFECT: method provides the effective entero- and pancreatoprotective action of the non-steroid anti-inflammatory preparations in simulating the gastric ulcer and/or pancreatitis experimentally with reducing the toxicity of the exposure.

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