FIELD: medicine.
SUBSTANCE: invention relates to medical virology and deals with an influenza virus strain. The vaccine strain B/60/Massachusetts/2012/10 is a reassortant, obtained by crossing the "wild" virus B/Massachusetts/2/2012 with the cold-adapted temperature-sensitive virus B/USSR/60/69 -attenuation donor. The strain B/60/Massachusetts/2012/10 is deposited in the State Collection of Viruses FSBI D.I.Ivanovsky Scientific Research Institute of Virology Russian Ministry of Health under No 2740, actively reproduces in developing chicken embryos at the optimal temperature of 32°C, is characterised by temperature sensitivity and cold-adaptedness and safety for laboratory animals. Reassortant inherited genes, which code surface antigens of virus hemagglutinin (HA) and neuraminidase (NA), from the epidemic parent virus and remaining six genes, which code internal non-glycosylated proteins, from the attenuation donor.
EFFECT: claimed invention can be applied in practical healthcare for the prevention of influenza morbidity among adults and children.
4 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| VACCINATING INFLUENZA VIRUS STRAIN B/60/WISCONSIN/2010/125 | 2012 |
|
RU2545695C2 |
| STRAIN OF INFLUENZA VIRUS A/17/INDIANA/11/72 (H3N2v) FOR PRODUCTION OF LIQUID INFLUENZA INTRANASAL VACCINE FOR ADULTS AND FOR CHILDREN | 2013 |
|
RU2545706C1 |
| INFLUENZA VIRUS STRAIN V/60/Phuket/2013/26 FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2015 |
|
RU2605926C1 |
| VACCINE STRAIN OF B/60/MALAYSIA/04/898 INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2009 |
|
RU2416639C1 |
| INFLUENZA VIRUS STRAIN FOR LIVING INFLUENZA INTRANASAL VACCINE FOR INFANTS AND ADULTS | 2005 |
|
RU2307161C2 |
| VACCINE STRAIN OF INFLUENZA B/60/COLORADO/2017/1 (VICTORIA LINE) FOR THE PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2019 |
|
RU2746274C2 |
| COLD-ADAPTED ATTENUATION DONOR, STRAIN OF INFLUENZA VIRUS B/SSSR/60/69/5252, INTENDED FOR PRODUCTION OF STRAINS OF LIVE INTRANASAL INFLUENZA VACCINE | 2021 |
|
RU2769672C1 |
| STRAIN OF INFLUENZA VIRUS B/60/JOHANNESBURG/99/50 FOR PRODUCTION OF LIVE (ANTI)-INFLUENZA INTRANASAL VACCINE FOR ADULT AND CHILDREN | 2002 |
|
RU2215786C1 |
| VACCINE STRAIN OF B/60/FLORIDA/04/181 INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2010 |
|
RU2422519C1 |
| REASSORTANT STRAIN OF INFLUENZA VIRUS B/60/WASHINGTON/2019/3676 (VICTORIA LINE) FOR THE PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2021 |
|
RU2757397C1 |
