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2 215 786

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C1

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IPC

(21) (22)

Application

2002107089/13, 2002-03-19

(24)

Start date

2002-03-19

(22)

Actual filing date

2002-03-19

(45)

Published

2003-11-10

(72)

Inventor

Desheva Ju.A.Larionova N.V.Aleksandrova G.I.Rudenko L.G.Klimov A.I.

(73)

Holder

Gu Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

STRAIN OF INFLUENZA VIRUS B/60/JOHANNESBURG/99/50 FOR PRODUCTION OF LIVE (ANTI)-INFLUENZA INTRANASAL VACCINE FOR ADULT AND CHILDREN Russian patent published in 2003 - IPC

Abstract RU 2215786 C1

FIELD: medicinal virology. SUBSTANCE: vaccine strain B/60/Johannesburg/99/50 is reassortant obtained by breeding epidemic virus B/Johannesburg/05/99 with cold-adapted temperature-sensitive virus B/USSR/60/69. The strain B/60/Johannesburg/99/50 multiplies actively in developing chicken embryos at optimal temperature 32- 33 C and characterized by temperature-sensitivity and cold-adaptation. Reassortant inherited two genes from epidemic virus encoding surface proteins (hemagglutinin and neuraminidase) and six genes encoding non- glycosylated proteins from attenuation donor. The strain can be used for adult and children 3-14 years age in intranasal administration and it satisfies immunogenicity indices. EFFECT: improved and valuable properties of strain. 3 tbl, 2 ex

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RU 2 215 786 C1

Authors

Desheva Ju.A.

Larionova N.V.

Aleksandrova G.I.

Rudenko L.G.

Klimov A.I.

Dates

2003-11-10—Published

2002-03-19—Filed

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