FIELD: medicine.
SUBSTANCE: B/60/Malaysia/04/898 strain actively replicates in growing chicken embryos at optimum temperature 32-33°C. It is characterised by thermal sensitivity and cold adaptation. A reassortant has inherited the genes coding surface virus antigens - hemagglutinin (HA) and neuraminidase (NA) from an epidemic parent virus. The other six genes code internal non-glycosylated proteins from an attenuation donor. The B/60/Malaysia/04/898 strain is areactogenic for adults and children in intranasal introduction.
EFFECT: invention can be used in practical health services for preventing seasonal influenza incidence in adults and children by a live influenza intranasal vaccine of the strain of said influenza virus.
4 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| VACCINE STRAIN OF B/60/FLORIDA/04/181 INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2010 |
|
RU2422519C1 |
| VACCINE STRAIN OF A/17/BRISBANE/07/1 (H3N2) INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2010 |
|
RU2416640C1 |
| VACCINE STRAIN OF A/17/SOLOMON ISLANDS/06/9 (H1N1) INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2010 |
|
RU2422518C1 |
| INFLUENZA VIRUS STRAIN B/60/MASSACHUSETTS/2012/10 FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2013 |
|
RU2546190C1 |
| STRAIN OF INFLUENZA VIRUS, GISK ¦ 147, USED FOR PREPARING INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2006 |
|
RU2319744C2 |
| STRAIN B/60/PETERBURGH/95/20 FOR PRODUCTION OF LIVING ANTIINFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 1997 |
|
RU2128224C1 |
| INFLUENZA VIRUS STRAIN FOR PRODUCING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2011 |
|
RU2464311C1 |
| INFLUENZA VIRUS STRAIN FOR PRODUCING LIVE AND INACTIVATED INFLUENZA VACCINE | 2011 |
|
RU2464309C1 |
| VACCINE STRAIN OF B/60/BRISBANE/08/83 INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2010 |
|
RU2422517C1 |
| INFLUENZA VIRUS STRAIN FOR LIVING INFLUENZA INTRANASAL VACCINE FOR INFANTS AND ADULTS | 2005 |
|
RU2307161C2 |
