METHOD FOR SYNTHESIS OF 2-THIOHISTIDINE AND ANALOGUES THEREOF Russian patent published in 2015 - IPC C07D233/84

Abstract RU 2548153 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method for synthesis of a 2-thiohistidine derivative of formula

from a compound of formula

via a cleavage reaction in the presence of a thiol at temperature of 60°C or higher, as well as to compounds of formula (II) and a method for synthesis thereof. In general formula (I), (II) R₁ and R₂ are independently a hydrogen atom and R₃ and R₄ are independently a hydrogen atom or a (C₁-C₄)alkyl group, R₅ and R₆ are a hydrogen atom.

EFFECT: improved synthesis method.

23 cl, 12 ex

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RU 2 548 153 C2

Authors

Ehrdel'Mejer Irehn

Done Sil'Ven

Dates

2015-04-20—Published

2010-10-06—Filed