FIELD: chemistry.
SUBSTANCE: invention relates to the method for producing (S)-1-(4-((2-(2-aminopyrimidine-5-yl)-7-methyl-4-morpholinotino[3,2-d]pyrimidine-6-yl)methyl)piperazine-1-yl)-2-hydroxypropan-1-ona having the structure:
,
and also to the new intermediate oxalate (S) -2-hydroxy-1-(piperazine-1-yl)propan-1-ona having the following structure:
A new method for producing (S)-1-(4-((2-(2-aminopyrimidine-5-yl)-7-methyl-4-morpholinotino[3,2-d]pyrimidine-6-yl)methyl)piperazine-1-yl)-2-hydroxypropan-1-ona, which is a double inhibitor of mTOR/PI3K GDC-0980.
EFFECT: new method of producing connections.
16cl, 1 tbl, 18 ex
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