ENANTIOMERICALLY PURE BASIC ARYLCYCLOALKYLHYDROXYCARBOXYLIC ACID ESTERS, METHOD FOR THEIR PREPARING AND APPLYING IN MEDICINAL AGENTS Russian patent published in 2004 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention relates to enantiomerically pure esters, namely to enantiomers with (3R,2'R)-, (3S,2'R)-, (3R,2'S)- and (3S,2'S)-configuration of the general formula (I):

wherein R₁ means monocyclic saturated (C₅-C₇)-cycloalkyl residue substituted, if necessary, with one or some (C₁-C₃)-alkyl residues or one or some halogen atoms, such as fluorine, chlorine, bromine and iodine; R₂ means (C₁-C₆)-alkyl, (C₂-C₆)-alkenyl or (C₂-C₆)-alkynyl residue that can be substituted, if necessary, with one or some halogen atoms, such as fluorine, chlorine, bromine or iodine; R₃ means (C₁-C₃)-alkyl residue; n means a whole number 1 or 2; AR means phenyl residue or 5-membered ring comprising sulfur as a heteroatom that can be substituted with one or some alkyl (C₁-C₃)-alkyl groups, groups CF₃, CN, NH₂, NO₂, alkoxy-groups and/or one or some similar or different halogen atoms; A means anion of pharmacologically acceptable acid and wherein OH, AR and R₁ groups are placed by clockwise from center of quaternary carbon atom to carboxyl group. Compounds of the formula (I) can be used as a medicinal agent used for treatment of obstructive diseases in respiratory ways, in particular, asthma and chronic bronchitis. Invention describes a method for preparing compounds of the formula (I).

EFFECT: improved preparing method, valuable medicinal properties of compounds.

11 cl, 5 tbl, 2 dwg, 19 ex