METHOD FOR PRODUCING METHYL 1-[3-(CYCLOHEXYLCARBAMOYL)-2-OXOCHROMAN-4-YL] CYCLOPENTACARBOXYLATE SHOWING ANALGESIC ACTIVITY Russian patent published in 2015 - IPC C07D311/20 

Abstract RU 2549357 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for producing methyl 1 -[3-(cyclohexylcarbamoyl)-2-oxochroman-4-yl]cyclopentanecarboxylate of formula (1) which consists in boiling 1-bromcyclopentanecarboxylic acid methyl ester with zinc and 2-oxo-2H-chromen-3-carboxylic acid cyclohexylamide in the medium of benzol - ethylacetate - hexamethylphosphorotriamide (10:5:1) for 4 hours.

EFFECT: produced compound is novel and possesses analgesic action.

1 tbl, 2 ex

Similar patents RU2549357C2

Title Year Author Number
METHOD FOR PRODUCING METHYL 1-[(1,3-DIOXO-2,3-DIHYDRO-1H-INDEN-2-YL)-(4-METHYLPHENYL)METHYL]CYCLOHEXANE CARBOXYLATE SHOWING ANALGESIC ACTIVITY 2013
  • Kirillov Nikolaj Fedorovich
  • Nikiforova Elena Aleksandrovna
  • Makhmudov Ramiz Ragibovich
  • Mardanova Ljudmila Gennad'Evna
RU2549566C2
USE OF N-[1-ARYL-3-OXO-2-AZASPIRO[3.5]NONAN-2-YL]BENZAMIDES AS ANALGESIC MEDICINAL PRODUCTS 2023
  • Nikiforova Elena Aleksandrovna
  • Zverev Dmitrii Pavlovich
  • Makhmudov Ramiz Ragibovich
  • Uchuskin Maksim Grigorevich
  • Mendogralo Elena Iurevna
  • Makarov Anton Sergeevich
  • Rubtsov Aleksandr Evgenevich
RU2810704C1
ETHYL2-ETHYL-2-(1-OXO-5-PHENYL-2-OXASPIRO[5,5]UNDEC-3-EN-3-YL)BUTANOATE, HAVING ANALGESIC ACTIVITY AND SYNTHESIS METHOD 2010
  • Kirillov Nikolaj Fedorovich
  • Makhmudov Ramiz Ragibovich
  • Nikiforova Elena Aleksandrovna
  • Mardanova Ljudmila Gennad'Evna
RU2453542C1
METHOD OF PRODUCING 5-ARYL-3-PHENYL-2-OXASPIRO[5,6]DODEC-3-EN-1-ONES, EXHIBITING ANALGESIC ACTIVITY 2011
  • Kirillov Nikolaj Fedorovich
  • Gavrilov Aleksandr Gennad'Evich
  • Makhmudov Ramiz Ragibovich
  • Mardanova Ljudmila Gennad'Evna
RU2461555C1
METHOD OF PRODUCING 5-ARYL-2-METHYL-1,3-DIOXO-2-AZASPIRO[5,5] UNDECANE-4-CARBONITRILES AND AGENT EXHIBITING ANALGESIC ACTIVITY 2011
  • Kirillov Nikolaj Fedorovich
  • Makhmudov Ramiz Ragibovich
  • Nikiforova Elena Aleksandrovna
  • Mardanova Ljudmila Gennad'Evna
RU2455284C1
USE OF N-[2-(1-OXO-3,5-DIPHENYL-2-AZASPIRO[5.5]UNDEC-3-EN-2 IL)PHENYL]-3-BROMOBENZAMIDE AS ANALGESIC 2023
  • Nikiforova Elena Aleksandrovna
  • Zverev Dmitrii Pavlovich
  • Makhmudov Ramiz Ragibovich
  • Uchuskin Maksim Grigorevich
  • Mendogralo Elena Iurevna
  • Makarov Anton Sergeevich
  • Rubtsov Aleksandr Evgenevich
RU2808999C1
-5-4-CHLOROPHENYL-3-[2-(4-CHLOROPHENYL)ETHENYL]-2-OXASPIRO[5,6]DODEC-3-EN-1-ONE, HAVING ANALGESIC ACTIVITY 2010
  • Kirillov Nikolaj Fedorovich
  • Gavrilov Aleksandr Gennad'Evich
  • Makhmudov Ramiz Ragibovich
  • Mardanova Ljudmila Gennad'Evna
RU2435767C1
(E)-4'-ARYL-7'-ARYLMETHYLENE-4',5',6',7'-TETRAHYDRO-2'H-SPIRO[CYCLOALKANE-1,3'-CYCLOPENTA[b]PYRAN]-2'-ONES, EXHIBITING ANALGESIC ACTIVITY AND SYNTHESIS METHOD THEREOF 2010
  • Kirillov Nikolaj Fedorovich
  • Makhmudov Ramiz Ragibovich
  • Gavrilov Aleksandr Gennad'Evich
  • Mardanova Ljudmila Gennad'Evna
RU2455300C2
1-[M-CARBOXAMIDO(HETERO)ARYL-METHYL]-HETEROCYCLYL-CARBOXAMIDE DERIVATIVES 2013
  • Fretts Khajnts
  • Gude Markus
  • Gerri Filipp
  • Kimmerlen Terri
  • Leembre Fransua
  • Pfajfer Tomas
  • Valdener Anya
RU2644761C2
USE OF 1'-ARYLDISPIRO[CYCLOALKANE-1,3'-AZETIDINE-2',3''-INDOLINE]-2'',4'-DIONES AS ANALGESICS 2023
  • Nikiforova Elena Aleksandrovna
  • Zverev Dmitrii Pavlovich
  • Makhmudov Ramiz Ragibovich
  • Uchuskin Maksim Grigorevich
  • Mendogralo Elena Iurevna
  • Makarov Anton Sergeevich
  • Rubtsov Aleksandr Evgenevich
  • Sergeeva Serafima Valerevna
RU2809008C1

RU 2 549 357 C2

Authors

Kirillov Nikolaj Fedorovich

Nikiforova Elena Aleksandrovna

Makhmudov Ramiz Ragibovich

Mardanova Ljudmila Gennad'Evna

Dates

2015-04-27Published

2013-06-04Filed