Show metadata Hide metadata

(19)

(11)

2 455 284

(13)

(51)

IPC

C07D221/20(2006-01-01)

A61K31/438(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2011109763/04, 2011-03-15

(24)

Start date

2011-03-15

(22)

Actual filing date

2011-03-15

(45)

Published

2012-07-10

(72)

Inventor

Kirillov Nikolaj FedorovichMakhmudov Ramiz RagibovichNikiforova Elena AleksandrovnaMardanova Ljudmila Gennad'Evna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Universitet"

METHOD OF PRODUCING 5-ARYL-2-METHYL-1,3-DIOXO-2-AZASPIRO[5,5] UNDECANE-4-CARBONITRILES AND AGENT EXHIBITING ANALGESIC ACTIVITY Russian patent published in 2012 - IPC C07D221/20 A61K31/438 A61P29/00

Abstract RU 2455284 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 5-aryl-2-methyl-1,3-dioxo-2-azaspiro[5,5] undecane-4-carbonitriles of general formula: where: Ar=Ph (a), 4-BrC₆H₄ (b), 4-ClC₆H₄ (c), 4-MeOC₆H₆(d), 3,4-(MeO)₂C₆H₃ (e), which involves boiling methyl ether of 1-bromocyclohexane carboxylic acid with zinc and 3-aryl-2-cyano-N-methylpropenamide in the medium of benzene-ethylacetate-HMPA (10:5:1) for 4 hours. The invention also relates to an agent which exhibits analgetic activity, which is one of 5-aryl-2-methyl-1,3-dioxo-2-azaspiro[5,5] undecane-4-carbonitriles obtained using the method described above.

EFFECT: obtaining novel 5-aryl-2-methyl-1,3-dioxo-2-azaspiro[5,5] undecane-4-carbonitriles and an agent exhibiting analgesic activity.

2 cl, 2 ex, 3 tbl

Similar patents RU2455284C1

Title	Year	Author	Number
USE OF N-[1-ARYL-3-OXO-2-AZASPIRO[3.5]NONAN-2-YL]BENZAMIDES AS ANALGESIC MEDICINAL PRODUCTS	2023	Nikiforova Elena Aleksandrovna Zverev Dmitrii Pavlovich Makhmudov Ramiz Ragibovich Uchuskin Maksim Grigorevich Mendogralo Elena Iurevna Makarov Anton Sergeevich Rubtsov Aleksandr Evgenevich	RU2810704C1
USE OF 3,3'-(1,4-PHENYLENE)BIS[2-ARYL-2-AZASPIRO[3.5]NONAN-1-ONES] AS AGENTS WITH ANALGESIC ACTIVITY	2023	Uchuskin Maksim Grigorevich Mendogralo Elena Iurevna Makarov Anton Sergeevich Nikiforova Elena Aleksandrovna Rubtsov Aleksandr Evgenevich Zverev Dmitrii Pavlovich Makhmudov Ramiz Ragibovich	RU2808986C1
USE OF 1'-ARYLDISPIRO[CYCLOALKANE-1,3'-AZETIDINE-2',3''-INDOLINE]-2'',4'-DIONES AS ANALGESICS	2023	Nikiforova Elena Aleksandrovna Zverev Dmitrii Pavlovich Makhmudov Ramiz Ragibovich Uchuskin Maksim Grigorevich Mendogralo Elena Iurevna Makarov Anton Sergeevich Rubtsov Aleksandr Evgenevich Sergeeva Serafima Valerevna	RU2809008C1
METHOD FOR PRODUCING METHYL 1-[(1,3-DIOXO-2,3-DIHYDRO-1H-INDEN-2-YL)-(4-METHYLPHENYL)METHYL]CYCLOHEXANE CARBOXYLATE SHOWING ANALGESIC ACTIVITY	2013	Kirillov Nikolaj Fedorovich Nikiforova Elena Aleksandrovna Makhmudov Ramiz Ragibovich Mardanova Ljudmila Gennad'Evna	RU2549566C2
USE OF 2-(4-BROMOPHENYL)-3-(2-PHENYLETHENYL)-2-AZASPIRO[3.5]NONAN-1-ONE AS AN AGENT WITH ANALGESIC ACTIVITY	2023	Uchuskin Maksim Grigorevich Mendogralo Elena Iurevna Makarov Anton Sergeevich Nikiforova Elena Aleksandrovna Rubtsov Aleksandr Evgenevich Zverev Dmitrii Pavlovich	RU2808988C1
USE OF N-[2-(1-OXO-3,5-DIPHENYL-2-AZASPIRO[5.5]UNDEC-3-EN-2 IL)PHENYL]-3-BROMOBENZAMIDE AS ANALGESIC	2023	Nikiforova Elena Aleksandrovna Zverev Dmitrii Pavlovich Makhmudov Ramiz Ragibovich Uchuskin Maksim Grigorevich Mendogralo Elena Iurevna Makarov Anton Sergeevich Rubtsov Aleksandr Evgenevich	RU2808999C1
3-SUBSTITUTED 4,4(5H)-DICARBONITRILE-5-PHENYLISOXAZOLINES, HAVING ANTIFUNGAL ACTIVITY	2009	Tyrkov Aleksej Georgievich Nosachev Svjatoslav Borisovich Degtjarev Oleg Vladimirovich Zhizhikina Viktorija Viktorovna	RU2412174C1
METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-1,6-DIPHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-6-STYRYL-1-PHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHOD FOR PREPARING THEM	2012	Maslivets Andrej Nikolaevich Bubnov Nikolaj Vladimirovich Silajchev Pavel Sergeevich Filimonov Valerij Olegovich Makhmudov Ramiz Ragibovich	RU2495039C1
(E)-4'-ARYL-7'-ARYLMETHYLENE-4',5',6',7'-TETRAHYDRO-2'H-SPIRO[CYCLOALKANE-1,3'-CYCLOPENTA[b]PYRAN]-2'-ONES, EXHIBITING ANALGESIC ACTIVITY AND SYNTHESIS METHOD THEREOF	2010	Kirillov Nikolaj Fedorovich Makhmudov Ramiz Ragibovich Gavrilov Aleksandr Gennad'Evich Mardanova Ljudmila Gennad'Evna	RU2455300C2
APPLICATION OF 3-(2-(4-NITROPHENYL)-2-OXOETHYLIDENE)MORPHOLIN-2-ONE AS ANTIMICROBIAL AGENT	2021	Maslivets Andrej Nikolaevich Tretyakov Nikita Alekseevich Balandina Svetlana Yurevna	RU2763728C1

RU 2 455 284 C1

Authors

Kirillov Nikolaj Fedorovich

Makhmudov Ramiz Ragibovich

Nikiforova Elena Aleksandrovna

Mardanova Ljudmila Gennad'Evna

Dates

2012-07-10—Published

2011-03-15—Filed