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2 455 284

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IPC

C07D221/20(2006-01-01)

A61K31/438(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2011109763/04, 2011-03-15

(24)

Start date

2011-03-15

(22)

Actual filing date

2011-03-15

(45)

Published

2012-07-10

(72)

Inventor

Kirillov Nikolaj FedorovichMakhmudov Ramiz RagibovichNikiforova Elena AleksandrovnaMardanova Ljudmila Gennad'Evna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Universitet"

METHOD OF PRODUCING 5-ARYL-2-METHYL-1,3-DIOXO-2-AZASPIRO[5,5] UNDECANE-4-CARBONITRILES AND AGENT EXHIBITING ANALGESIC ACTIVITY Russian patent published in 2012 - IPC C07D221/20 A61K31/438 A61P29/00

Abstract RU 2455284 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 5-aryl-2-methyl-1,3-dioxo-2-azaspiro[5,5] undecane-4-carbonitriles of general formula: where: Ar=Ph (a), 4-BrC₆H₄ (b), 4-ClC₆H₄ (c), 4-MeOC₆H₆(d), 3,4-(MeO)₂C₆H₃ (e), which involves boiling methyl ether of 1-bromocyclohexane carboxylic acid with zinc and 3-aryl-2-cyano-N-methylpropenamide in the medium of benzene-ethylacetate-HMPA (10:5:1) for 4 hours. The invention also relates to an agent which exhibits analgetic activity, which is one of 5-aryl-2-methyl-1,3-dioxo-2-azaspiro[5,5] undecane-4-carbonitriles obtained using the method described above.

EFFECT: obtaining novel 5-aryl-2-methyl-1,3-dioxo-2-azaspiro[5,5] undecane-4-carbonitriles and an agent exhibiting analgesic activity.

2 cl, 2 ex, 3 tbl

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RU 2 455 284 C1

Authors

Kirillov Nikolaj Fedorovich

Makhmudov Ramiz Ragibovich

Nikiforova Elena Aleksandrovna

Mardanova Ljudmila Gennad'Evna

Dates

2012-07-10—Published

2011-03-15—Filed