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2 549 566

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IPC

C07C69/757(2006-01-01)

C07C67/313(2006-01-01)

A61K31/216(2006-01-01)

A61P29/00(2006-01-01)

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Application

2013125801/04, 2013-06-04

(24)

Start date

2013-06-04

(22)

Actual filing date

2013-06-04

(45)

Published

2015-04-27

(72)

Inventor

Kirillov Nikolaj FedorovichNikiforova Elena AleksandrovnaMakhmudov Ramiz RagibovichMardanova Ljudmila Gennad'Evna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Natsional'Nyj Issledovatel'Skij Universitet"

METHOD FOR PRODUCING METHYL 1-[(1,3-DIOXO-2,3-DIHYDRO-1H-INDEN-2-YL)-(4-METHYLPHENYL)METHYL]CYCLOHEXANE CARBOXYLATE SHOWING ANALGESIC ACTIVITY Russian patent published in 2015 - IPC C07C69/757 C07C67/313 A61K31/216 A61P29/00

Abstract RU 2549566 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to organic chemistry, namely to a method for producing methyl 1-[(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-(4-methylphenyl)methyl]cyclohexane carboxylate (I) consisting in the fact that 1-bromcyclohexane carboxylic acid methyl ester is boiled with zinc and 2-(4-methylbenzylidene)-1H-indene-1,3(2H)-dione in the medium of benzol - ethylacelate - hexamethylphosphotriamide (10:5:1) for 8 hours with 67% yield.

EFFECT: prepared compound possesses analgesic activity.

1 tbl, 2 ex

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RU 2 549 566 C2

Authors

Kirillov Nikolaj Fedorovich

Nikiforova Elena Aleksandrovna

Makhmudov Ramiz Ragibovich

Mardanova Ljudmila Gennad'Evna

Dates

2015-04-27—Published

2013-06-04—Filed