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2 549 572

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IPC

C07D285/135(2006-01-01)

A61K31/433(2006-01-01)

A61P29/00(2006-01-01)

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Application

2013134779/04, 2013-07-23

(24)

Start date

2013-07-23

(22)

Actual filing date

2013-07-23

(45)

Published

2015-04-27

(72)

Inventor

Pulina Natal'Ja AlekseevnaKozhukhar' Vjacheslav Jur'EvichKrasnova Anastasija IvanovnaJushkova Tat'Jana Aleksandrovna

(73)

Holder

Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennaja Farmatsevticheskaja Akademija" Ministerstva Zdravookhranenija Rossijskoj Federatsii Vpo Pgfa Minzdrava Rossii)

2-(5-ETHYL-1,3,4-THIADIAZOLYL)AMIDE OF 2-(4-BROMOPHENYL)-4-OXO-4-PHENYL-2-BUTENOIC ACID, HAVING ANALGESIC EFFECT Russian patent published in 2015 - IPC C07D285/135 A61K31/433 A61P29/00

Abstract RU 2549572 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, novel biologically active substances of the class of N-hetarylamides of 4-aryl-2,4-dioxobutanoic acids, and specifically to 2-(5-ethyl-1,3,4-thiadiazolyl)amide of 2-(4-bromophenyl)-4-oxo-4-phenyl-2-butenoic acid. The compound is obtained by reacting 4-bromophenyl-5-aryl-3-imino-3H-furan-2-one with 2-amino-5-ethyl-1,3,4-thiadiazole with equimolar ratio of reactants in a medium of anhydrous toluene while boiling, followed by separation of the end product.

EFFECT: obtaining compounds having analgesic effect, as well as low toxicity

1 tbl

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RU 2 549 572 C2

Authors

Pulina Natal'Ja Alekseevna

Kozhukhar' Vjacheslav Jur'Evich

Krasnova Anastasija Ivanovna

Jushkova Tat'Jana Aleksandrovna

Dates

2015-04-27—Published

2013-07-23—Filed