FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry and specifically to novel biologically active substances of the class of 4-aryl-2,4-dioxobutanoic acids. Disclosed is 4-(4-bromophenyl)-4-oxo-2-{[3-ethoxycarbonyl)-4,5-dimethylthien-2-yl]amino}-2-butenoic acid, having anti-inflammatory and analgesic activity, of formula (1): 
.
EFFECT: obtaining a compound with high output, having marked anti-inflammatory and analgesic activity as well as low toxicity.
1 cl, 1 tbl
| Title |
Year |
Author |
Number |
| 4-(4-METHYLPHENYL)-4-OXO-2-[3-(ETHOXYCARBONYL-4,5-R,R-THIOPHEN-2-YLAMINO]BUT-2-ENOIC ACID, HAVING ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY |
2008 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgen'Evich
- Makhmudov Ramiz Ragipovich
- Zalesov Vladimir Vasil'Evich
|
RU2389724C1 |
| (Z)-2-[(3-CARBAMOYL-4,5,6,7-TETRAHYDROBENZO[b]THIEN-2-YL)AMINO]-4-(4-R-PHENYL)-4-OXOBUT-2-ENOIC ACIDS, HAVING ANALGESIC ACTIVITY |
2012 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgen'Evich
- Makhmudov Ramiz Ragibovich
|
RU2503671C1 |
| 4-OXO-2-{[4-PHENYL-3-(ETHOXYCARBONYL)THIOPHEN-2-YL]AMINO)}-4-(4-FLUOROPHENYL)BUT-2-ENOIC ACID, HAVING ANTI-INFLAMMATORY ACTIVITY |
2024 |
- Shipilovskikh Sergej Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Gorbunova Irina Aleksandrovna
- Sharaveva Yuliya Olegovna
|
RU2831129C1 |
| N-R-AMIDES OF (Z)-2[(3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO [b]THIEN-2-YL)AMINO]-4-PHENYL-4-OXOBUT-2-ENOIC ACIDS, HAVING ANALGESIC ACTIVITY |
2012 |
- Shipilovskikh Sergej Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Rubtsov Aleksandr Evgen'Evich
|
RU2501795C1 |
| APPLICATION OF 4-(4-BROMOPHENYL)-2-[2-(4-NITROBENZOYL)HYDRAZONO]-4-OXOBUTANOIC ACID AS AN ANTI-INFLAMMATORY DRUG |
2022 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
- Igidov Nazim Musabekovich
|
RU2785781C1 |
| 2-{4-[2-(N,N-DIETHYLAMINO)ETHOXYCARBONYL]PHENYL} AMNO-4-OXO-4-R-PHENYL-2-BUTENOIC ACIDS HAVING ANALGESIC ACTIVITY |
2009 |
- Nekrasov Denis Denisovich
- Unizhuk Ekaterina Gennad'Evna
- Makhmudov Ramiz Ragibovich
|
RU2405767C1 |
| 2-(1,2-DIPHENYL-2-OXOETHYLIDENEHYDRAZINO)-4-(4-METHOXYPHENYL)-4-OXOBUT-2-ENE ACID WITH ANTI-INFLAMMATORY AND ANALGESIC EFFECT |
2006 |
- Pulina Natal'Ja Alekseevna
- Zalesov Vladimir Vasil'Evich
- Bystritskaja Oksana Anatol'Evna
- Jushkov Vladimir Viktorovich
- Jatsenko Konstantin Vjacheslavovich
|
RU2348613C2 |
| APPLICATION OF 2-[(3-(AMINOCARBONIL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-yl)AMINO]-4-OXO-4-(4-CHLOROPHENYL)BUT-2-ENOIC ACID IN AS AN ANTI-INFLAMMATORY DRUG |
2022 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Rubtsov Aleksandr Evgenevich
|
RU2785780C1 |
| 1,6-DIOXO-1-METHOXY-6-PHENYL-2-CYANO-4-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)AMINO)HEXA-2,4-DIENE-3-OLATE OF POTASSIUM, HAVING ANTI-INFLAMMATORY ACTIVITY |
2024 |
- Shipilovskikh Sergej Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrij Vladimirovich
|
RU2829961C1 |
| 2-(5-ETHYL-1,3,4-THIADIAZOLYL)AMIDE OF 2-(4-BROMOPHENYL)-4-OXO-4-PHENYL-2-BUTENOIC ACID, HAVING ANALGESIC EFFECT |
2013 |
- Pulina Natal'Ja Alekseevna
- Kozhukhar' Vjacheslav Jur'Evich
- Krasnova Anastasija Ivanovna
- Jushkova Tat'Jana Aleksandrovna
|
RU2549572C2 |
